Invasive aspergillosis: results of multicenter study

Invasive aspergillosis: results of multicenter study

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<p>We present the results of a multicenter study of 445 patients with “proven” and “probable” invasive aspergillosis (EORTC/MSG, 2008). Invasive aspergillosis usually occurs in patients with hematological malignancies (88 %), main underlying diseases were acute myeloid and acute lymphoblastic...

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Main Authors: N. N. Klimko, O. V. Shadrivova, S. N. Khostelidi, E. A. Desyatik, Yu. V. Borzova, R. M. Chernopyatova, E. V. Shagdileeva, A. G. Volkova, M. O. Popova, I. S. Zyuzgin, O. S. Ruzhinskaya, O. Ye. Ryabykina, N. V. Medvedeva, A. S. Kolbin, E. G. Boychenko, T. S. Bogomolova, S. M. Ignatieva, L. S. Zubarovskaya, B. V. Afanasiev
Format: Article
Language:Russian
Published: ABV-press 2014-09-01
Series:Onkogematologiâ
Subjects:
Aspergillus
invasive aspergillosis
hematological malignancies
voriconazole
Online Access:http://oncohematology.abvpress.ru/index.php/ongm/article/view/110
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author N. N. Klimko
O. V. Shadrivova
S. N. Khostelidi
E. A. Desyatik
Yu. V. Borzova
R. M. Chernopyatova
E. V. Shagdileeva
A. G. Volkova
M. O. Popova
I. S. Zyuzgin
O. S. Ruzhinskaya
O. Ye. Ryabykina
N. V. Medvedeva
A. S. Kolbin
E. G. Boychenko
T. S. Bogomolova
S. M. Ignatieva
L. S. Zubarovskaya
B. V. Afanasiev
spellingShingle N. N. Klimko
O. V. Shadrivova
S. N. Khostelidi
E. A. Desyatik
Yu. V. Borzova
R. M. Chernopyatova
E. V. Shagdileeva
A. G. Volkova
M. O. Popova
I. S. Zyuzgin
O. S. Ruzhinskaya
O. Ye. Ryabykina
N. V. Medvedeva
A. S. Kolbin
E. G. Boychenko
T. S. Bogomolova
S. M. Ignatieva
L. S. Zubarovskaya
B. V. Afanasiev
Invasive aspergillosis: results of multicenter study
Onkogematologiâ
Aspergillus
invasive aspergillosis
hematological malignancies
voriconazole
author_facet N. N. Klimko
O. V. Shadrivova
S. N. Khostelidi
E. A. Desyatik
Yu. V. Borzova
R. M. Chernopyatova
E. V. Shagdileeva
A. G. Volkova
M. O. Popova
I. S. Zyuzgin
O. S. Ruzhinskaya
O. Ye. Ryabykina
N. V. Medvedeva
A. S. Kolbin
E. G. Boychenko
T. S. Bogomolova
S. M. Ignatieva
L. S. Zubarovskaya
B. V. Afanasiev
author_sort N. N. Klimko
title Invasive aspergillosis: results of multicenter study
title_short Invasive aspergillosis: results of multicenter study
title_full Invasive aspergillosis: results of multicenter study
title_fullStr Invasive aspergillosis: results of multicenter study
title_full_unstemmed Invasive aspergillosis: results of multicenter study
title_sort invasive aspergillosis: results of multicenter study
publisher ABV-press
series Onkogematologiâ
issn 1818-8346
publishDate 2014-09-01
description <p>We present the results of a multicenter study of 445 patients with “proven” and “probable” invasive aspergillosis (EORTC/MSG, 2008). Invasive aspergillosis usually occurs in patients with hematological malignancies (88 %), main underlying diseases were acute myeloid and acute lymphoblastic leukemia. The risk factors: prolonged agranulocytosis (64 %), cytostatic chemotherapy (57 %), corticosteroid treatment (45 %), and allogeneic hematopoietic stem cells transplantation (29 %). The pathogens – A. fumigatus (42 %), A. niger (33 %), and A. flavus (21 %). The main site of infection were lungs (86 %). 12 week overall survival was 83 %. Bronchoscopy use for the early diagnosis (p = 0.01), adequate<br />therapy with voriconazole (p = 0.002) and secondary antifungal prophylaxis (p = 0.0003) were positive prognostic factors for survival of patients with invasive aspergillosis.</p>
topic Aspergillus
invasive aspergillosis
hematological malignancies
voriconazole
url http://oncohematology.abvpress.ru/index.php/ongm/article/view/110
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spelling doaj-1984ab2a900f45df814ebb8c2dec57242020-11-24T22:45:21ZrusABV-pressOnkogematologiâ1818-83462014-09-01921319125Invasive aspergillosis: results of multicenter studyN. N. Klimko0O. V. Shadrivova1S. N. Khostelidi2E. A. Desyatik3Yu. V. Borzova4R. M. Chernopyatova5E. V. Shagdileeva6A. G. Volkova7M. O. Popova8I. S. Zyuzgin9O. S. Ruzhinskaya10O. Ye. Ryabykina11N. V. Medvedeva12A. S. Kolbin13E. G. Boychenko14T. S. Bogomolova15S. M. Ignatieva16L. S. Zubarovskaya17B. V. Afanasiev18P.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and ImmunologyP.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgP.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgP.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgP.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgP.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgP.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaLeningrad Regional Hospital, Saint PetersburgLeningrad Regional Hospital, Saint PetersburgLeningrad Regional Hospital, Saint PetersburgMunicipal Hospital № 31, Saint PetersburgChildren Municipal Hospital № 1, Saint PetersburgChildren Municipal Hospital № 1, Saint PetersburgP.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgP.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia<p>We present the results of a multicenter study of 445 patients with “proven” and “probable” invasive aspergillosis (EORTC/MSG, 2008). Invasive aspergillosis usually occurs in patients with hematological malignancies (88 %), main underlying diseases were acute myeloid and acute lymphoblastic leukemia. The risk factors: prolonged agranulocytosis (64 %), cytostatic chemotherapy (57 %), corticosteroid treatment (45 %), and allogeneic hematopoietic stem cells transplantation (29 %). The pathogens – A. fumigatus (42 %), A. niger (33 %), and A. flavus (21 %). The main site of infection were lungs (86 %). 12 week overall survival was 83 %. Bronchoscopy use for the early diagnosis (p = 0.01), adequate<br />therapy with voriconazole (p = 0.002) and secondary antifungal prophylaxis (p = 0.0003) were positive prognostic factors for survival of patients with invasive aspergillosis.</p>http://oncohematology.abvpress.ru/index.php/ongm/article/view/110Aspergillusinvasive aspergillosishematological malignanciesvoriconazole

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