Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease

Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease

Abstract Background Astrocytes provide a vital support to neurons in normal and pathological conditions. In Alzheimer’s disease (AD) brains, reactive astrocytes have been found surrounding amyloid plaques, forming an astrocytic scar. However, their role and potential mechanisms whereby they affect n...

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Bibliographic Details
Main Authors: Nicola Davis, Bibiana C. Mota, Larissa Stead, Emily O. C. Palmer, Laura Lombardero, Rafael Rodríguez-Puertas, Vincenzo de Paola, Samuel J. Barnes, Magdalena Sastre
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Neuroinflammation
Subjects:
Astrocytes
L-AAA
Cytokines
Amyloid-β
Synapsis
Online Access:https://doi.org/10.1186/s12974-021-02117-y

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