An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis
Our understanding of the functional link between differential DNA methylation and type 2 diabetes and obesity remains limited. Here the authors present a blood-based EWAS of fasting glucose and insulin among 4808 non-diabetic Europeans and identify nine CpGs not previously implicated in glucose, ins...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10487-4 |
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doaj-19891659495247948d3d723f24545ddd |
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jun Liu Elena Carnero-Montoro Jenny van Dongen Samantha Lent Ivana Nedeljkovic Symen Ligthart Pei-Chien Tsai Tiphaine C. Martin Pooja R. Mandaviya Rick Jansen Marjolein J. Peters Liesbeth Duijts Vincent W. V. Jaddoe Henning Tiemeier Janine F. Felix Gonneke Willemsen Eco J. C. de Geus Audrey Y. Chu Daniel Levy Shih-Jen Hwang Jan Bressler Rahul Gondalia Elias L. Salfati Christian Herder Bertha A. Hidalgo Toshiko Tanaka Ann Zenobia Moore Rozenn N. Lemaitre Min A Jhun Jennifer A. Smith Nona Sotoodehnia Stefania Bandinelli Luigi Ferrucci Donna K. Arnett Harald Grallert Themistocles L. Assimes Lifang Hou Andrea Baccarelli Eric A. Whitsel Ko Willems van Dijk Najaf Amin André G. Uitterlinden Eric J. G. Sijbrands Oscar H. Franco Abbas Dehghan Tim D. Spector Josée Dupuis Marie-France Hivert Jerome I. Rotter James B. Meigs James S. Pankow Joyce B. J. van Meurs Aaron Isaacs Dorret I. Boomsma Jordana T. Bell Ayşe Demirkan Cornelia M. van Duijn |
| spellingShingle |
Jun Liu Elena Carnero-Montoro Jenny van Dongen Samantha Lent Ivana Nedeljkovic Symen Ligthart Pei-Chien Tsai Tiphaine C. Martin Pooja R. Mandaviya Rick Jansen Marjolein J. Peters Liesbeth Duijts Vincent W. V. Jaddoe Henning Tiemeier Janine F. Felix Gonneke Willemsen Eco J. C. de Geus Audrey Y. Chu Daniel Levy Shih-Jen Hwang Jan Bressler Rahul Gondalia Elias L. Salfati Christian Herder Bertha A. Hidalgo Toshiko Tanaka Ann Zenobia Moore Rozenn N. Lemaitre Min A Jhun Jennifer A. Smith Nona Sotoodehnia Stefania Bandinelli Luigi Ferrucci Donna K. Arnett Harald Grallert Themistocles L. Assimes Lifang Hou Andrea Baccarelli Eric A. Whitsel Ko Willems van Dijk Najaf Amin André G. Uitterlinden Eric J. G. Sijbrands Oscar H. Franco Abbas Dehghan Tim D. Spector Josée Dupuis Marie-France Hivert Jerome I. Rotter James B. Meigs James S. Pankow Joyce B. J. van Meurs Aaron Isaacs Dorret I. Boomsma Jordana T. Bell Ayşe Demirkan Cornelia M. van Duijn An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis Nature Communications |
| author_facet |
Jun Liu Elena Carnero-Montoro Jenny van Dongen Samantha Lent Ivana Nedeljkovic Symen Ligthart Pei-Chien Tsai Tiphaine C. Martin Pooja R. Mandaviya Rick Jansen Marjolein J. Peters Liesbeth Duijts Vincent W. V. Jaddoe Henning Tiemeier Janine F. Felix Gonneke Willemsen Eco J. C. de Geus Audrey Y. Chu Daniel Levy Shih-Jen Hwang Jan Bressler Rahul Gondalia Elias L. Salfati Christian Herder Bertha A. Hidalgo Toshiko Tanaka Ann Zenobia Moore Rozenn N. Lemaitre Min A Jhun Jennifer A. Smith Nona Sotoodehnia Stefania Bandinelli Luigi Ferrucci Donna K. Arnett Harald Grallert Themistocles L. Assimes Lifang Hou Andrea Baccarelli Eric A. Whitsel Ko Willems van Dijk Najaf Amin André G. Uitterlinden Eric J. G. Sijbrands Oscar H. Franco Abbas Dehghan Tim D. Spector Josée Dupuis Marie-France Hivert Jerome I. Rotter James B. Meigs James S. Pankow Joyce B. J. van Meurs Aaron Isaacs Dorret I. Boomsma Jordana T. Bell Ayşe Demirkan Cornelia M. van Duijn |
| author_sort |
Jun Liu |
| title |
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
| title_short |
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
| title_full |
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
| title_fullStr |
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
| title_full_unstemmed |
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
| title_sort |
integrative cross-omics analysis of dna methylation sites of glucose and insulin homeostasis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-06-01 |
| description |
Our understanding of the functional link between differential DNA methylation and type 2 diabetes and obesity remains limited. Here the authors present a blood-based EWAS of fasting glucose and insulin among 4808 non-diabetic Europeans and identify nine CpGs not previously implicated in glucose, insulin homeostasis and diabetes. |
| url |
https://doi.org/10.1038/s41467-019-10487-4 |
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| _version_ |
1721444556072812544 |
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doaj-19891659495247948d3d723f24545ddd2021-05-11T12:32:06ZengNature Publishing GroupNature Communications2041-17232019-06-0110111110.1038/s41467-019-10487-4An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasisJun Liu0Elena Carnero-Montoro1Jenny van Dongen2Samantha Lent3Ivana Nedeljkovic4Symen Ligthart5Pei-Chien Tsai6Tiphaine C. Martin7Pooja R. Mandaviya8Rick Jansen9Marjolein J. Peters10Liesbeth Duijts11Vincent W. V. Jaddoe12Henning Tiemeier13Janine F. Felix14Gonneke Willemsen15Eco J. C. de Geus16Audrey Y. Chu17Daniel Levy18Shih-Jen Hwang19Jan Bressler20Rahul Gondalia21Elias L. Salfati22Christian Herder23Bertha A. Hidalgo24Toshiko Tanaka25Ann Zenobia Moore26Rozenn N. Lemaitre27Min A Jhun28Jennifer A. Smith29Nona Sotoodehnia30Stefania Bandinelli31Luigi Ferrucci32Donna K. Arnett33Harald Grallert34Themistocles L. Assimes35Lifang Hou36Andrea Baccarelli37Eric A. Whitsel38Ko Willems van Dijk39Najaf Amin40André G. Uitterlinden41Eric J. G. Sijbrands42Oscar H. Franco43Abbas Dehghan44Tim D. Spector45Josée Dupuis46Marie-France Hivert47Jerome I. Rotter48James B. Meigs49James S. Pankow50Joyce B. J. van Meurs51Aaron Isaacs52Dorret I. Boomsma53Jordana T. Bell54Ayşe Demirkan55Cornelia M. van Duijn56Department of Epidemiology, Erasmus University Medical CenterDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit AmsterdamDepartment of Biostatistics, Boston University School of Public HealthDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Twin Research and Genetic Epidemiology, King’s College LondonDepartment of Twin Research and Genetic Epidemiology, King’s College LondonDepartment of Internal Medicine, Section of Pharmacology Vascular and Metabolic Diseases, Erasmus University Medical CenterDepartment of Psychiatry and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit AmsterdamDepartment of Internal Medicine, Section of Pharmacology Vascular and Metabolic Diseases, Erasmus University Medical CenterDivision of Neonatology, Department of Pediatrics, Erasmus University Medical CenterDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Child and Adolescent Psychiatry, Erasmus University Medical CenterDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit AmsterdamDepartment of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit AmsterdamThe Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of HealthThe Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of HealthThe Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of HealthHuman Genetics Center, School of Public Health, University of Texas Health Science Center at HoustonDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaDepartment of Medicine, Stanford University School of MedicineGerman Center for Diabetes Research (DZD)Department of Epidemiology, University of Alabama at BirminghamTranslational Gerontology Branch, National Institute on AgingTranslational Gerontology Branch, National Institute on AgingCardiovascular Health Research Unit, Department of Medicine, University of WashingtonDepartment of Epidemiology, School of Public Health, University of MichiganDepartment of Epidemiology, School of Public Health, University of MichiganCardiovascular Health Research Unit, Department of Medicine, University of WashingtonGeriatric Unit, Azienda Sanitaria di FirenzeTranslational Gerontology Branch, National Institute on AgingSchool of Public Health, University of KentuckyGerman Center for Diabetes Research (DZD)Department of Medicine, Stanford University School of MedicineCenter for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University ChicagoDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia UniversityDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaDepartment of Human Genetics, Leiden University Medical CenterDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Internal Medicine, Section of Pharmacology Vascular and Metabolic Diseases, Erasmus University Medical CenterDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Twin Research and Genetic Epidemiology, King’s College LondonDepartment of Biostatistics, Boston University School of Public HealthDepartment of Medicine, Université de SherbrookeThe Institute for Translational Genomics and Population Sciences and Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterDepartment of Medicine, Harvard Medical SchoolDivision of Epidemiology and Community Health, School of Public Health, University of MinnesotaCARIM School for Cardiovascular Diseases, Maastricht Centre for Systems Biology (MaCSBio), and Departments of Biochemistry and Physiology, Maastricht UniversityDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit AmsterdamDepartment of Twin Research and Genetic Epidemiology, King’s College LondonDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Epidemiology, Erasmus University Medical CenterOur understanding of the functional link between differential DNA methylation and type 2 diabetes and obesity remains limited. Here the authors present a blood-based EWAS of fasting glucose and insulin among 4808 non-diabetic Europeans and identify nine CpGs not previously implicated in glucose, insulin homeostasis and diabetes.https://doi.org/10.1038/s41467-019-10487-4 |