Comparison of the 2-step tuberculin skin test and QuantiFERON-TB Gold in-Tube test in the screening of latent tuberculosis infection in cancer patients
Interferon-γ release assay (IGRA) may improve the diagnostic accuracy for latent tuberculosis infection (LTBI). The aim of this study was to compare the performance of the QuantiFERON-TB Gold-in-Tube (QFT-GIT), with the tuberculin skin test (TST) (one and two step TST) in detection of LTBI in immuno...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2015-07-01
|
Series: | Egyptian Journal of Chest Disease and Tuberculosis |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S042276381520129X |
id |
doaj-19a128cfccd94ffda92e009fd8f77c99 |
---|---|
record_format |
Article |
spelling |
doaj-19a128cfccd94ffda92e009fd8f77c992020-11-25T00:56:20ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382015-07-0164368168810.1016/j.ejcdt.2015.03.032Comparison of the 2-step tuberculin skin test and QuantiFERON-TB Gold in-Tube test in the screening of latent tuberculosis infection in cancer patientsHala A. Mohammad0Mona A. Esmail1Mohammad T. Abdelftah2Wael Soliman3Abdelfatah mohammad4Emad esmail5Chest Department, Faculty of Medicine, Minia University, EgyptMicrobiology and Immunology Department, Faculty of Medicine Minia University, EgyptChest Department, Faculty of Medicine, Minia University, EgyptTropical Medicine, Faculty of Medicine Minia University, EgyptInternal Medicine Department, Faculty of Medicine Minia University, EgyptMinia Oncology Institute, EgyptInterferon-γ release assay (IGRA) may improve the diagnostic accuracy for latent tuberculosis infection (LTBI). The aim of this study was to compare the performance of the QuantiFERON-TB Gold-in-Tube (QFT-GIT), with the tuberculin skin test (TST) (one and two step TST) in detection of LTBI in immunocompromised cancer patients. The study was carried out on 50 patients and 20 healthy subjects as a control group. Patients with active TB or AIDS were excluded. A TSTI was only positive in 2 patients (4%). The TSTII (booster phenomena) was positive in 8 patients (16%) after 3–4 weeks. Ten patients (20%) had positive Quantiferon test while the test was indeterminate in 14 patients (28%). Hematological malignancy group (HMgroup) had significantly more positive TSTII results followed by the breast cancer group (p = 0.01). Similarly, QFT-GIT positive values were significantly more frequent in the HM group. This study suggests that the QFT-GIT test maintains its sensitivity and performance in immunocompromised cancer patients, identifying a large number of truly infected patients being anergy to the tuberculin skin test.http://www.sciencedirect.com/science/article/pii/S042276381520129XTuberculin skin testQuantiFERON-TB Gold-in-TubeCancer patients |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hala A. Mohammad Mona A. Esmail Mohammad T. Abdelftah Wael Soliman Abdelfatah mohammad Emad esmail |
spellingShingle |
Hala A. Mohammad Mona A. Esmail Mohammad T. Abdelftah Wael Soliman Abdelfatah mohammad Emad esmail Comparison of the 2-step tuberculin skin test and QuantiFERON-TB Gold in-Tube test in the screening of latent tuberculosis infection in cancer patients Egyptian Journal of Chest Disease and Tuberculosis Tuberculin skin test QuantiFERON-TB Gold-in-Tube Cancer patients |
author_facet |
Hala A. Mohammad Mona A. Esmail Mohammad T. Abdelftah Wael Soliman Abdelfatah mohammad Emad esmail |
author_sort |
Hala A. Mohammad |
title |
Comparison of the 2-step tuberculin skin test and QuantiFERON-TB Gold in-Tube test in the screening of latent tuberculosis infection in cancer patients |
title_short |
Comparison of the 2-step tuberculin skin test and QuantiFERON-TB Gold in-Tube test in the screening of latent tuberculosis infection in cancer patients |
title_full |
Comparison of the 2-step tuberculin skin test and QuantiFERON-TB Gold in-Tube test in the screening of latent tuberculosis infection in cancer patients |
title_fullStr |
Comparison of the 2-step tuberculin skin test and QuantiFERON-TB Gold in-Tube test in the screening of latent tuberculosis infection in cancer patients |
title_full_unstemmed |
Comparison of the 2-step tuberculin skin test and QuantiFERON-TB Gold in-Tube test in the screening of latent tuberculosis infection in cancer patients |
title_sort |
comparison of the 2-step tuberculin skin test and quantiferon-tb gold in-tube test in the screening of latent tuberculosis infection in cancer patients |
publisher |
Wolters Kluwer Medknow Publications |
series |
Egyptian Journal of Chest Disease and Tuberculosis |
issn |
0422-7638 |
publishDate |
2015-07-01 |
description |
Interferon-γ release assay (IGRA) may improve the diagnostic accuracy for latent tuberculosis infection (LTBI). The aim of this study was to compare the performance of the QuantiFERON-TB Gold-in-Tube (QFT-GIT), with the tuberculin skin test (TST) (one and two step TST) in detection of LTBI in immunocompromised cancer patients.
The study was carried out on 50 patients and 20 healthy subjects as a control group. Patients with active TB or AIDS were excluded. A TSTI was only positive in 2 patients (4%). The TSTII (booster phenomena) was positive in 8 patients (16%) after 3–4 weeks. Ten patients (20%) had positive Quantiferon test while the test was indeterminate in 14 patients (28%).
Hematological malignancy group (HMgroup) had significantly more positive TSTII results followed by the breast cancer group (p = 0.01). Similarly, QFT-GIT positive values were significantly more frequent in the HM group. This study suggests that the QFT-GIT test maintains its sensitivity and performance in immunocompromised cancer patients, identifying a large number of truly infected patients being anergy to the tuberculin skin test. |
topic |
Tuberculin skin test QuantiFERON-TB Gold-in-Tube Cancer patients |
url |
http://www.sciencedirect.com/science/article/pii/S042276381520129X |
work_keys_str_mv |
AT halaamohammad comparisonofthe2steptuberculinskintestandquantiferontbgoldintubetestinthescreeningoflatenttuberculosisinfectionincancerpatients AT monaaesmail comparisonofthe2steptuberculinskintestandquantiferontbgoldintubetestinthescreeningoflatenttuberculosisinfectionincancerpatients AT mohammadtabdelftah comparisonofthe2steptuberculinskintestandquantiferontbgoldintubetestinthescreeningoflatenttuberculosisinfectionincancerpatients AT waelsoliman comparisonofthe2steptuberculinskintestandquantiferontbgoldintubetestinthescreeningoflatenttuberculosisinfectionincancerpatients AT abdelfatahmohammad comparisonofthe2steptuberculinskintestandquantiferontbgoldintubetestinthescreeningoflatenttuberculosisinfectionincancerpatients AT emadesmail comparisonofthe2steptuberculinskintestandquantiferontbgoldintubetestinthescreeningoflatenttuberculosisinfectionincancerpatients |
_version_ |
1725227622733971456 |