Effect of Alkyl Chain Length on Adsorption and Release of Hydrophobic Drug to/from Hydrophobically-modified Gelatin Hydrogel
Hydrogels have become popular as drug carriers. Controlled release of the drugs from hydrogels can reduce dosage, inducing prevention of side effects. However, the hydrophilicity of hydrogels interferes with controlled release of hydrophobic drugs such as anticancer agents or antibiotics. In this st...
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EDP Sciences
2021-01-01
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Online Access: | https://www.matec-conferences.org/articles/matecconf/pdf/2021/02/matecconf_apcche21_11008.pdf |
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doaj-19a26d10fb604fb189dfc2a0d55552612021-01-15T10:19:30ZengEDP SciencesMATEC Web of Conferences2261-236X2021-01-013331100810.1051/matecconf/202133311008matecconf_apcche21_11008Effect of Alkyl Chain Length on Adsorption and Release of Hydrophobic Drug to/from Hydrophobically-modified Gelatin HydrogelFukuhara YoshikiOhzuno YshihiroTakei TakayukiYoshida MasahiroHydrogels have become popular as drug carriers. Controlled release of the drugs from hydrogels can reduce dosage, inducing prevention of side effects. However, the hydrophilicity of hydrogels interferes with controlled release of hydrophobic drugs such as anticancer agents or antibiotics. In this study, we developed hydrophobically-modified gelatin (HMG) hydrogel, which was cross-linked only by hydrophobic interaction. HMG does not require toxic chemical cross-linkers to form hydrogel. In addition, the HMG hydrogel has hydrophobic chambers in its structure which hydrophobic drugs can adsorb to and desorb from. In order to control the amount of hydrophobic drugs adsorbed into the hydrogel, hydrophobic alkyl chains with different lengths (C4-C12) were incorporated into gelatin molecules. Uranine was used as a model for hydrophobic drugs. The adsorption test exhibited that the amount of uranine adsorbed in HMG hydrogels could be controlled by varying hydrophobic alkyl chain length and that the drug could be released in a controlled manner. These results show that HMG hydrogels are promising carriers of hydrophobic drugs.https://www.matec-conferences.org/articles/matecconf/pdf/2021/02/matecconf_apcche21_11008.pdf |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fukuhara Yoshiki Ohzuno Yshihiro Takei Takayuki Yoshida Masahiro |
spellingShingle |
Fukuhara Yoshiki Ohzuno Yshihiro Takei Takayuki Yoshida Masahiro Effect of Alkyl Chain Length on Adsorption and Release of Hydrophobic Drug to/from Hydrophobically-modified Gelatin Hydrogel MATEC Web of Conferences |
author_facet |
Fukuhara Yoshiki Ohzuno Yshihiro Takei Takayuki Yoshida Masahiro |
author_sort |
Fukuhara Yoshiki |
title |
Effect of Alkyl Chain Length on Adsorption and Release of Hydrophobic Drug to/from Hydrophobically-modified Gelatin Hydrogel |
title_short |
Effect of Alkyl Chain Length on Adsorption and Release of Hydrophobic Drug to/from Hydrophobically-modified Gelatin Hydrogel |
title_full |
Effect of Alkyl Chain Length on Adsorption and Release of Hydrophobic Drug to/from Hydrophobically-modified Gelatin Hydrogel |
title_fullStr |
Effect of Alkyl Chain Length on Adsorption and Release of Hydrophobic Drug to/from Hydrophobically-modified Gelatin Hydrogel |
title_full_unstemmed |
Effect of Alkyl Chain Length on Adsorption and Release of Hydrophobic Drug to/from Hydrophobically-modified Gelatin Hydrogel |
title_sort |
effect of alkyl chain length on adsorption and release of hydrophobic drug to/from hydrophobically-modified gelatin hydrogel |
publisher |
EDP Sciences |
series |
MATEC Web of Conferences |
issn |
2261-236X |
publishDate |
2021-01-01 |
description |
Hydrogels have become popular as drug carriers. Controlled release of the drugs from hydrogels can reduce dosage, inducing prevention of side effects. However, the hydrophilicity of hydrogels interferes with controlled release of hydrophobic drugs such as anticancer agents or antibiotics. In this study, we developed hydrophobically-modified gelatin (HMG) hydrogel, which was cross-linked only by hydrophobic interaction. HMG does not require toxic chemical cross-linkers to form hydrogel. In addition, the HMG hydrogel has hydrophobic chambers in its structure which hydrophobic drugs can adsorb to and desorb from. In order to control the amount of hydrophobic drugs adsorbed into the hydrogel, hydrophobic alkyl chains with different lengths (C4-C12) were incorporated into gelatin molecules. Uranine was used as a model for hydrophobic drugs. The adsorption test exhibited that the amount of uranine adsorbed in HMG hydrogels could be controlled by varying hydrophobic alkyl chain length and that the drug could be released in a controlled manner. These results show that HMG hydrogels are promising carriers of hydrophobic drugs. |
url |
https://www.matec-conferences.org/articles/matecconf/pdf/2021/02/matecconf_apcche21_11008.pdf |
work_keys_str_mv |
AT fukuharayoshiki effectofalkylchainlengthonadsorptionandreleaseofhydrophobicdrugtofromhydrophobicallymodifiedgelatinhydrogel AT ohzunoyshihiro effectofalkylchainlengthonadsorptionandreleaseofhydrophobicdrugtofromhydrophobicallymodifiedgelatinhydrogel AT takeitakayuki effectofalkylchainlengthonadsorptionandreleaseofhydrophobicdrugtofromhydrophobicallymodifiedgelatinhydrogel AT yoshidamasahiro effectofalkylchainlengthonadsorptionandreleaseofhydrophobicdrugtofromhydrophobicallymodifiedgelatinhydrogel |
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1724337369723699200 |