Clinical variables associated with leprosy reactions and persistence of physical impairment
Introduction Leprosy is a chronic disease that affects skin and peripheral nerves. Disease complications include reactional episodes and physical impairment. One World Health Organization (WHO) goal of leprosy programs is to decrease the number of grade 2 impairment diagnoses by 2015. This study aim...
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doaj-19bb6b7b0b0747ae99210d6ccde3d4922020-11-24T22:56:58ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492013-10-0146560060410.1590/0037-8682-0100-2013S0037-86822013000500600Clinical variables associated with leprosy reactions and persistence of physical impairmentDaniela Teles de OliveiraJonnia SherlockEnaldo Vieira de MeloKarla Caroline Vieira RollembergTelma Rodrigues Santos da PaixaoYasmin Gama AbuawadMarise do Vale SimonMalcolm DuthieAmelia Ribeiro de JesusIntroduction Leprosy is a chronic disease that affects skin and peripheral nerves. Disease complications include reactional episodes and physical impairment. One World Health Organization (WHO) goal of leprosy programs is to decrease the number of grade 2 impairment diagnoses by 2015. This study aims to evaluate clinical factors associated with the occurrence of leprosy reactions and physical impairment in leprosy patients. Methods We conducted a retrospective study of data from medical records of patients followed in two important centers for the treatment of leprosy in Aracaju, Sergipe, Brazil, from 2005 to 2011. We used the chi-square test to analyze associations between the following categorical variables: gender, age, operational classification, clinical forms, leprosy reactions, corticosteroid treatment, and physical impairment at the diagnosis and after cure. Clinical variables associated with multibacillary leprosy and/or reactional episodes and the presence of any grade of physical impairment after cure were evaluated using the logistic regression model. Results We found that men were more affected by multibacillary forms, reactional episodes, and grade 2 physical impairment at diagnosis. Leprosy reactions were detected in a total of 40% of patients and all were treated with corticosteroids. However, physical impairment was observed in 29.8% of the patients analyzed at the end of the treatment and our multivariate analysis associated a low dose and short period of corticosteroid treatment with persistence of physical impairments. Conclusions Physical impairment should receive an increased attention before and after treatment, and adequate treatment should be emphasized.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500600&lng=en&tlng=enLeprosyLeprosy reactionsPhysical impairmentCorticosteroid treatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniela Teles de Oliveira Jonnia Sherlock Enaldo Vieira de Melo Karla Caroline Vieira Rollemberg Telma Rodrigues Santos da Paixao Yasmin Gama Abuawad Marise do Vale Simon Malcolm Duthie Amelia Ribeiro de Jesus |
spellingShingle |
Daniela Teles de Oliveira Jonnia Sherlock Enaldo Vieira de Melo Karla Caroline Vieira Rollemberg Telma Rodrigues Santos da Paixao Yasmin Gama Abuawad Marise do Vale Simon Malcolm Duthie Amelia Ribeiro de Jesus Clinical variables associated with leprosy reactions and persistence of physical impairment Revista da Sociedade Brasileira de Medicina Tropical Leprosy Leprosy reactions Physical impairment Corticosteroid treatment |
author_facet |
Daniela Teles de Oliveira Jonnia Sherlock Enaldo Vieira de Melo Karla Caroline Vieira Rollemberg Telma Rodrigues Santos da Paixao Yasmin Gama Abuawad Marise do Vale Simon Malcolm Duthie Amelia Ribeiro de Jesus |
author_sort |
Daniela Teles de Oliveira |
title |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
title_short |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
title_full |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
title_fullStr |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
title_full_unstemmed |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
title_sort |
clinical variables associated with leprosy reactions and persistence of physical impairment |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
series |
Revista da Sociedade Brasileira de Medicina Tropical |
issn |
1678-9849 |
publishDate |
2013-10-01 |
description |
Introduction Leprosy is a chronic disease that affects skin and peripheral nerves. Disease complications include reactional episodes and physical impairment. One World Health Organization (WHO) goal of leprosy programs is to decrease the number of grade 2 impairment diagnoses by 2015. This study aims to evaluate clinical factors associated with the occurrence of leprosy reactions and physical impairment in leprosy patients. Methods We conducted a retrospective study of data from medical records of patients followed in two important centers for the treatment of leprosy in Aracaju, Sergipe, Brazil, from 2005 to 2011. We used the chi-square test to analyze associations between the following categorical variables: gender, age, operational classification, clinical forms, leprosy reactions, corticosteroid treatment, and physical impairment at the diagnosis and after cure. Clinical variables associated with multibacillary leprosy and/or reactional episodes and the presence of any grade of physical impairment after cure were evaluated using the logistic regression model. Results We found that men were more affected by multibacillary forms, reactional episodes, and grade 2 physical impairment at diagnosis. Leprosy reactions were detected in a total of 40% of patients and all were treated with corticosteroids. However, physical impairment was observed in 29.8% of the patients analyzed at the end of the treatment and our multivariate analysis associated a low dose and short period of corticosteroid treatment with persistence of physical impairments. Conclusions Physical impairment should receive an increased attention before and after treatment, and adequate treatment should be emphasized. |
topic |
Leprosy Leprosy reactions Physical impairment Corticosteroid treatment |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500600&lng=en&tlng=en |
work_keys_str_mv |
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