Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in Mice
Arsenic is a toxic metalloid. Infants with a low birth-weight have been observed in areas with high-level arsenic in drinking water ranging from 463 to 1025 μg/L. A distal muscular atrophy side effect has been observed in acute promyelocytic leukemia patients treated with arsenic trioxide (As<sub...
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doaj-19bc01ba12794a6b9bac369eedf43d862020-11-25T03:24:23ZengMDPI AGMolecules1420-30492020-07-01253057305710.3390/molecules25133057Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in MiceChang-Mu Chen0Min-Ni Chung1Chen-Yuan Chiu2Shing-Hwa Liu3Kuo-Cheng Lan4Department of Surgery, College of Medicine and Hospital, National Taiwan University, Taipei 100, TaiwanInstitute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, TaiwanDepartment of Botanicals, Medical and Pharmaceutical Industry Technology and Development Center, New Taipei City 248, TaiwanInstitute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, TaiwanDepartment of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanArsenic is a toxic metalloid. Infants with a low birth-weight have been observed in areas with high-level arsenic in drinking water ranging from 463 to 1025 μg/L. A distal muscular atrophy side effect has been observed in acute promyelocytic leukemia patients treated with arsenic trioxide (As<sub>2</sub>O<sub>3</sub>) for therapy. The potential of As<sub>2</sub>O<sub>3</sub> on muscle atrophy remains to be clarified. In this study, the myoatrophic effect of arsenic was evaluated in normal mice and sciatic nerve denervated mice exposed with or without As<sub>2</sub>O<sub>3</sub> (0.05 and 0.5 ppm) in drinking water for 4 weeks. We found that both 0.05 and 0.5 ppm As<sub>2</sub>O<sub>3</sub> increased the fasting plasma glucose level; but only 0.5 ppm arsenic exposure significantly decreased muscle mass, muscle endurance, and cross-sectional area of muscle fibers, and increased muscle Atrogin-1 protein expression in the normal mice. Both 0.05 and 0.5 ppm As<sub>2</sub>O<sub>3</sub> also significantly enhanced the inhibitory effects on muscle endurance, muscle mass, and cross-sectional area of muscle fibers, and increased the effect on muscle Atrogin-1 protein expression in the denervated mice. These in vivo results suggest that inorganic arsenic at doses relevant to humans may possess myoatrophic potential.https://www.mdpi.com/1420-3049/25/13/3057arsenicskeletal muscledenervationatrophy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chang-Mu Chen Min-Ni Chung Chen-Yuan Chiu Shing-Hwa Liu Kuo-Cheng Lan |
spellingShingle |
Chang-Mu Chen Min-Ni Chung Chen-Yuan Chiu Shing-Hwa Liu Kuo-Cheng Lan Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in Mice Molecules arsenic skeletal muscle denervation atrophy |
author_facet |
Chang-Mu Chen Min-Ni Chung Chen-Yuan Chiu Shing-Hwa Liu Kuo-Cheng Lan |
author_sort |
Chang-Mu Chen |
title |
Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in Mice |
title_short |
Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in Mice |
title_full |
Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in Mice |
title_fullStr |
Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in Mice |
title_full_unstemmed |
Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in Mice |
title_sort |
inorganic arsenic exposure decreases muscle mass and enhances denervation-induced muscle atrophy in mice |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-07-01 |
description |
Arsenic is a toxic metalloid. Infants with a low birth-weight have been observed in areas with high-level arsenic in drinking water ranging from 463 to 1025 μg/L. A distal muscular atrophy side effect has been observed in acute promyelocytic leukemia patients treated with arsenic trioxide (As<sub>2</sub>O<sub>3</sub>) for therapy. The potential of As<sub>2</sub>O<sub>3</sub> on muscle atrophy remains to be clarified. In this study, the myoatrophic effect of arsenic was evaluated in normal mice and sciatic nerve denervated mice exposed with or without As<sub>2</sub>O<sub>3</sub> (0.05 and 0.5 ppm) in drinking water for 4 weeks. We found that both 0.05 and 0.5 ppm As<sub>2</sub>O<sub>3</sub> increased the fasting plasma glucose level; but only 0.5 ppm arsenic exposure significantly decreased muscle mass, muscle endurance, and cross-sectional area of muscle fibers, and increased muscle Atrogin-1 protein expression in the normal mice. Both 0.05 and 0.5 ppm As<sub>2</sub>O<sub>3</sub> also significantly enhanced the inhibitory effects on muscle endurance, muscle mass, and cross-sectional area of muscle fibers, and increased the effect on muscle Atrogin-1 protein expression in the denervated mice. These in vivo results suggest that inorganic arsenic at doses relevant to humans may possess myoatrophic potential. |
topic |
arsenic skeletal muscle denervation atrophy |
url |
https://www.mdpi.com/1420-3049/25/13/3057 |
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