Electrodes in the brain—Ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders
Background: Deep brain stimulation (DBS) has been used for neuropsychiatric disorders in clinical and research settings for almost 50 years now. Recent evidence demonstrates some efficacy in treating obsessive-compulsive disorder and major depression in patients refractory to other treatment modalit...
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doaj-19bc84a7f2e446ba94749a4c0366530c2021-03-18T04:34:49ZengElsevierBrain Stimulation1935-861X2011-01-0141716Electrodes in the brain—Ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disordersMatthis Synofzik0Thomas E. Schlaepfer1Department for Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, GermanyDepartment of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany; Departments of Psychiatry and Mental Health, The Johns Hopkins University, Baltimore, Maryland; Correspondence: Thomas E. Schlaepfer, MD, Department of Psychiatry/University Hospital, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.Background: Deep brain stimulation (DBS) has been used for neuropsychiatric disorders in clinical and research settings for almost 50 years now. Recent evidence demonstrates some efficacy in treating obsessive-compulsive disorder and major depression in patients refractory to other treatment modalities beyond single case reports. This has led to a considerable surge of clinical and commercial interest in DBS for psychiatric indications. Because of the high vulnerability of psychiatric patients, the lack of extensive short- and long-term data about effectiveness and the rapid spread of questionable indications this new field in psychiatry requires ethical criteria that can be applied to both research and clinical decision-making. Objective and Methods: We here present an evidence-based systematic ethical analysis of psychiatric DBS using the criteria of beneficence, nonmaleficence, and autonomy. Results and Conclusions: The proposed criteria are helpful in analyzing empirical evidence, informing research investigations and guiding clinical decision-making. This will prepare the ground for ethically justified, empirically comprehensive DBS in this highly vulnerable population and allow stringent future societal discussions about its legitimation.http://www.sciencedirect.com/science/article/pii/S1935861X10000203deep brain stimulationneuroethicsmajor depression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matthis Synofzik Thomas E. Schlaepfer |
spellingShingle |
Matthis Synofzik Thomas E. Schlaepfer Electrodes in the brain—Ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders Brain Stimulation deep brain stimulation neuroethics major depression |
author_facet |
Matthis Synofzik Thomas E. Schlaepfer |
author_sort |
Matthis Synofzik |
title |
Electrodes in the brain—Ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders |
title_short |
Electrodes in the brain—Ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders |
title_full |
Electrodes in the brain—Ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders |
title_fullStr |
Electrodes in the brain—Ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders |
title_full_unstemmed |
Electrodes in the brain—Ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders |
title_sort |
electrodes in the brain—ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2011-01-01 |
description |
Background: Deep brain stimulation (DBS) has been used for neuropsychiatric disorders in clinical and research settings for almost 50 years now. Recent evidence demonstrates some efficacy in treating obsessive-compulsive disorder and major depression in patients refractory to other treatment modalities beyond single case reports. This has led to a considerable surge of clinical and commercial interest in DBS for psychiatric indications. Because of the high vulnerability of psychiatric patients, the lack of extensive short- and long-term data about effectiveness and the rapid spread of questionable indications this new field in psychiatry requires ethical criteria that can be applied to both research and clinical decision-making. Objective and Methods: We here present an evidence-based systematic ethical analysis of psychiatric DBS using the criteria of beneficence, nonmaleficence, and autonomy. Results and Conclusions: The proposed criteria are helpful in analyzing empirical evidence, informing research investigations and guiding clinical decision-making. This will prepare the ground for ethically justified, empirically comprehensive DBS in this highly vulnerable population and allow stringent future societal discussions about its legitimation. |
topic |
deep brain stimulation neuroethics major depression |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X10000203 |
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