Imaging the L-type amino acid transporter-1 (LAT1) with Zr-89 immunoPET.

Imaging the L-type amino acid transporter-1 (LAT1) with Zr-89 immunoPET.

The L-type amino acid transporter-1 (LAT1, SLC7A5) is upregulated in a wide range of human cancers, positively correlated with the biological aggressiveness of tumors, and a promising target for both imaging and therapy. Radiolabeled amino acids such as O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET) that...

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Bibliographic Details
Main Authors: Oluwatayo F Ikotun, Bernadette V Marquez, Chaofeng Huang, Kazue Masuko, Miyamoto Daiji, Takashi Masuko, Jonathan McConathy, Suzanne E Lapi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3797081?pdf=render

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http://europepmc.org/articles/PMC3797081?pdf=render

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