Morphological Outer Retina Findings in Multiple Sclerosis Patients With or Without Optic Neuritis
Purpose: To investigate on the morphology of the macular inner (IR) and outer (OR) layers in multiple sclerosis (MS) patients with and without history of optic neuritis (ON), followed by good or poor recovery of best corrected visual acuity (BCVA).Methods: Thirty-five normal control subjects and 93...
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doaj-19c0f97818524fe7a9ff20c018d5197e2020-11-25T03:06:34ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-09-011110.3389/fneur.2020.00858564361Morphological Outer Retina Findings in Multiple Sclerosis Patients With or Without Optic NeuritisLucia Ziccardi0Lucilla Barbano1Laura Boffa2Maria Albanese3Andrzej Grzybowski4Andrzej Grzybowski5Diego Centonze6Diego Centonze7Vincenzo Parisi8Istituto di Ricovero e Cura a Carattere Scientifico - Fondazione Bietti, Rome, ItalyIstituto di Ricovero e Cura a Carattere Scientifico - Fondazione Bietti, Rome, ItalyUnit of Neurology, Department of Systems Medicine, Tor Vergata University, Rome, ItalyUnit of Neurology, Department of Systems Medicine, Tor Vergata University, Rome, ItalyDepartment of Ophthalmology, University of Warmia and Mazury, Olsztyn, PolandInstitute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan, PolandUnit of Neurology, Department of Systems Medicine, Tor Vergata University, Rome, ItalyIstituto di Ricovero e Cura a Carattere Scientifico Neuromed - Unit of Neurology and Neurorehabilitation, Pozzilli, ItalyIstituto di Ricovero e Cura a Carattere Scientifico - Fondazione Bietti, Rome, ItalyPurpose: To investigate on the morphology of the macular inner (IR) and outer (OR) layers in multiple sclerosis (MS) patients with and without history of optic neuritis (ON), followed by good or poor recovery of best corrected visual acuity (BCVA).Methods: Thirty-five normal control subjects and 93 relapsing remitting MS patients were enrolled. Of this, 40 MS patients without ON (MS-noON, 40 eyes), 27 with history of ON and good BCVA recovery (MS-ON-G, 27 eyes), and 26 with history of ON and poor BCVA recovery (MS-ON-P, 26 eyes) were studied. Controls and MS patients underwent an extensive ophthalmological examination including spectral-domain optical coherence tomography evaluating in 3 localized macular areas (0–1 mm, Area 1; 1–3 mm, Area 2; 3- 6 mm, Area 3), volumes (MV), and thicknesses (MT) of the whole retina (WR), further segmented in IR and OR. The differences of MV and MT between the groups were tested by ANOVA. In the MS-ON-P group, the correlations between MV and MT and BCVA were evaluated by Pearson's test.Results: When compared to controls, the MS-noON group showed not significantly (p > 0.01) different MVs, whereas MTs were significantly (p < 0.01) reduced in the evaluation of WR and IR. In the MS-ON-G group, a significant (p < 0.01) reduction of WR and IR MVs and MTs was found in Areas 2 and 3; OR MVs and MTs were similar (p > 0.01) to controls. In the MS-ON-P group a significant (p < 0.01) reduction of WR, IR, and OR MVs and MTs was detected in all areas; the BCVA reduction was significantly (p < 0.01) correlated with WR and IR MVs and MTs.Conclusions: In MS without history of ON or when ON is followed by a good BCVA recovery, the neurodegenerative process is limited to IR macular layers; in the presence of ON, with a poor BCVA recovery, a morphological impairment of both IR and OR macular layers occurs.https://www.frontiersin.org/article/10.3389/fneur.2020.00858/fullmultiple sclerosisoptic neuritis (ON)SD-OCT imagingneurodegenerationouter retina |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucia Ziccardi Lucilla Barbano Laura Boffa Maria Albanese Andrzej Grzybowski Andrzej Grzybowski Diego Centonze Diego Centonze Vincenzo Parisi |
spellingShingle |
Lucia Ziccardi Lucilla Barbano Laura Boffa Maria Albanese Andrzej Grzybowski Andrzej Grzybowski Diego Centonze Diego Centonze Vincenzo Parisi Morphological Outer Retina Findings in Multiple Sclerosis Patients With or Without Optic Neuritis Frontiers in Neurology multiple sclerosis optic neuritis (ON) SD-OCT imaging neurodegeneration outer retina |
author_facet |
Lucia Ziccardi Lucilla Barbano Laura Boffa Maria Albanese Andrzej Grzybowski Andrzej Grzybowski Diego Centonze Diego Centonze Vincenzo Parisi |
author_sort |
Lucia Ziccardi |
title |
Morphological Outer Retina Findings in Multiple Sclerosis Patients With or Without Optic Neuritis |
title_short |
Morphological Outer Retina Findings in Multiple Sclerosis Patients With or Without Optic Neuritis |
title_full |
Morphological Outer Retina Findings in Multiple Sclerosis Patients With or Without Optic Neuritis |
title_fullStr |
Morphological Outer Retina Findings in Multiple Sclerosis Patients With or Without Optic Neuritis |
title_full_unstemmed |
Morphological Outer Retina Findings in Multiple Sclerosis Patients With or Without Optic Neuritis |
title_sort |
morphological outer retina findings in multiple sclerosis patients with or without optic neuritis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2020-09-01 |
description |
Purpose: To investigate on the morphology of the macular inner (IR) and outer (OR) layers in multiple sclerosis (MS) patients with and without history of optic neuritis (ON), followed by good or poor recovery of best corrected visual acuity (BCVA).Methods: Thirty-five normal control subjects and 93 relapsing remitting MS patients were enrolled. Of this, 40 MS patients without ON (MS-noON, 40 eyes), 27 with history of ON and good BCVA recovery (MS-ON-G, 27 eyes), and 26 with history of ON and poor BCVA recovery (MS-ON-P, 26 eyes) were studied. Controls and MS patients underwent an extensive ophthalmological examination including spectral-domain optical coherence tomography evaluating in 3 localized macular areas (0–1 mm, Area 1; 1–3 mm, Area 2; 3- 6 mm, Area 3), volumes (MV), and thicknesses (MT) of the whole retina (WR), further segmented in IR and OR. The differences of MV and MT between the groups were tested by ANOVA. In the MS-ON-P group, the correlations between MV and MT and BCVA were evaluated by Pearson's test.Results: When compared to controls, the MS-noON group showed not significantly (p > 0.01) different MVs, whereas MTs were significantly (p < 0.01) reduced in the evaluation of WR and IR. In the MS-ON-G group, a significant (p < 0.01) reduction of WR and IR MVs and MTs was found in Areas 2 and 3; OR MVs and MTs were similar (p > 0.01) to controls. In the MS-ON-P group a significant (p < 0.01) reduction of WR, IR, and OR MVs and MTs was detected in all areas; the BCVA reduction was significantly (p < 0.01) correlated with WR and IR MVs and MTs.Conclusions: In MS without history of ON or when ON is followed by a good BCVA recovery, the neurodegenerative process is limited to IR macular layers; in the presence of ON, with a poor BCVA recovery, a morphological impairment of both IR and OR macular layers occurs. |
topic |
multiple sclerosis optic neuritis (ON) SD-OCT imaging neurodegeneration outer retina |
url |
https://www.frontiersin.org/article/10.3389/fneur.2020.00858/full |
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