Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients
The aim of the present study was to investigate the association of <em>APOE</em>, <em>MTHFR</em> and <em>ACE</em> polymorphisms with stroke in the Zambian population. We analyzed 41 stroke patients and 116 control subjects all of Zambian origin for associations be...
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doaj-19dc6a0bba97459e8ce1c9151b4352742021-01-02T08:24:05ZengMDPI AGNeurology International2035-83852035-83772013-11-0154e20e2010.4081/ni.2013.e202664Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patientsMasharip Atadzhanov0Mwila H. Mwaba1Patrice N. Mukomena2Shabir Lakhi3Sruti Rayaprolu4Owen A. Ross5James F. Meschia6Department of Internal Medicine, School of Medicine, University of Zambia, LusakaDepartment of Internal Medicine, School of Medicine, University of Zambia, LusakaDepartment of Internal Medicine, School of Medicine, University of Zambia, LusakaDepartment of Internal Medicine, School of Medicine, University of Zambia, LusakaDepartment of Neuroscience, Mayo Clinic, Jacksonville, FLDepartment of Neuroscience, Mayo Clinic, Jacksonville, FLDepartment of Neurology, Mayo Clinic, Jacksonville, FLThe aim of the present study was to investigate the association of <em>APOE</em>, <em>MTHFR</em> and <em>ACE</em> polymorphisms with stroke in the Zambian population. We analyzed 41 stroke patients and 116 control subjects all of Zambian origin for associations between the genotype of the <em>APOE</em>, <em>MTHFR</em> and <em>ACE</em> polymorphisms and stroke. The <em>APOE</em> ε2ε4 genotype showed increased risk for hemorrhagic stroke (P<0.05) and also a high risk for ischemic stroke (P=0.05). There was complete absence of the <em>APOE</em> ε2ε2 and the <em>MTHFR</em> TT genotypes in the Zambian population. The difference between cases and controls was not significant for the other genetic variants when analyzed for relationship between stroke, stroke subtype and genotype. We show that genetic variation at the <em>APOE locus</em> affects susceptibility to stroke. No detectable association were observed for the <em>MTHFR</em> and <em>ACE</em> genotypes and stroke in the Zambian population.http://www.pagepress.org/journals/index.php/ni/article/view/4698Sub-Saharan Africa, Zambia, ischemic stroke, intra-cerebral hemorrhage, outcome, risks factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masharip Atadzhanov Mwila H. Mwaba Patrice N. Mukomena Shabir Lakhi Sruti Rayaprolu Owen A. Ross James F. Meschia |
spellingShingle |
Masharip Atadzhanov Mwila H. Mwaba Patrice N. Mukomena Shabir Lakhi Sruti Rayaprolu Owen A. Ross James F. Meschia Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients Neurology International Sub-Saharan Africa, Zambia, ischemic stroke, intra-cerebral hemorrhage, outcome, risks factors |
author_facet |
Masharip Atadzhanov Mwila H. Mwaba Patrice N. Mukomena Shabir Lakhi Sruti Rayaprolu Owen A. Ross James F. Meschia |
author_sort |
Masharip Atadzhanov |
title |
Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients |
title_short |
Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients |
title_full |
Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients |
title_fullStr |
Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients |
title_full_unstemmed |
Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients |
title_sort |
association of the apoe, mthfr and ace genes polymorphisms and stroke in zambian patients |
publisher |
MDPI AG |
series |
Neurology International |
issn |
2035-8385 2035-8377 |
publishDate |
2013-11-01 |
description |
The aim of the present study was to investigate the association of <em>APOE</em>, <em>MTHFR</em> and <em>ACE</em> polymorphisms with stroke in the Zambian population. We analyzed 41 stroke patients and 116 control subjects all of Zambian origin for associations between the genotype of the <em>APOE</em>, <em>MTHFR</em> and <em>ACE</em> polymorphisms and stroke. The <em>APOE</em> ε2ε4 genotype showed increased risk for hemorrhagic stroke (P<0.05) and also a high risk for ischemic stroke (P=0.05). There was complete absence of the <em>APOE</em> ε2ε2 and the <em>MTHFR</em> TT genotypes in the Zambian population. The difference between cases and controls was not significant for the other genetic variants when analyzed for relationship between stroke, stroke subtype and genotype. We show that genetic variation at the <em>APOE locus</em> affects susceptibility to stroke. No detectable association were observed for the <em>MTHFR</em> and <em>ACE</em> genotypes and stroke in the Zambian population. |
topic |
Sub-Saharan Africa, Zambia, ischemic stroke, intra-cerebral hemorrhage, outcome, risks factors |
url |
http://www.pagepress.org/journals/index.php/ni/article/view/4698 |
work_keys_str_mv |
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