<b>The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution<b>
The degradation of propranolol hydrochloride (1-isopropylamino-3-(naphthoxy)-2-propranolol) in an aqueous solution was analyzed when irradiated by light UV, with and without β-cyclodextrin. There was an increase in the compound´s photostability in nanocavity when compared with the drug without the c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade Estadual de Maringá
2014-04-01
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| Series: | Acta Scientiarum: Technology |
| Subjects: | |
| Online Access: | http://186.233.154.254/ojs/index.php/ActaSciTechnol/article/view/17554 |
| Summary: | The degradation of propranolol hydrochloride (1-isopropylamino-3-(naphthoxy)-2-propranolol) in an aqueous solution was analyzed when irradiated by light UV, with and without β-cyclodextrin. There was an increase in the compound´s photostability in nanocavity when compared with the drug without the cyclodextrins’ cavity. First order kinetic model was employed for the degradation of propranolol in aqueous media and in cyclodextrins’ cavity. The kinetic parameter was obtained by the drug´s absorption and electronic fluorescence. As a rule, encapsulation of propranolol in β-cyclodextrin decreases photodegradation speed by 53%. |
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| ISSN: | 1806-2563 1807-8664 |