Deprescribing of Inappropriately Consumed Proton Pump Inhibitors and its Clinical Consequences
The study aimed to deprescribe inappropriate consumption among Proton Pump Inhibitor (PPI) users and assess the clinical consequences of deprescribing. This is a prospective interventional study carried out among patients aged >18 years and consuming PPI. The “potentially inappropriate” patients...
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Light House Polyclinic Mangalore
2021-08-01
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doaj-19e2ea3b134c434c8a64bb0901db9c5f2021-09-05T05:57:29ZengLight House Polyclinic Mangalore Online Journal of Health & Allied Sciences0972-59972021-08-01202Deprescribing of Inappropriately Consumed Proton Pump Inhibitors and its Clinical ConsequencesApoorva Rachana Kulkarni0Harsha Prakash Nair1Eswaran Maheswari2Avinash Balekuduru3Ganesan Rajalekshmi Saraswathy4Ann Mary Swaroop5Department of Pharmacy Practice, M.S. Ramaiah College of Pharmacy, Bangalore, Karnataka, IndiaDepartment of Pharmacy Practice, M.S. Ramaiah College of Pharmacy, Bangalore, Karnataka, IndiaDepartment of Pharmacy Practice, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, IndiaDepartment of Gastroenterology, M.S. Ramaiah Hospitals, Bangalore, Karnataka, IndiaDepartment of Pharmacy Practice, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, IndiaDepartment of Pharmacy Practice, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, IndiaThe study aimed to deprescribe inappropriate consumption among Proton Pump Inhibitor (PPI) users and assess the clinical consequences of deprescribing. This is a prospective interventional study carried out among patients aged >18 years and consuming PPI. The “potentially inappropriate” patients were counselled on harms of inappropriate PPI usage, impact of healthy dietary and lifestyle habits employing a Patient Information Leaflet (PIL). The patients deprescribed were followed up through telephonic communication. Global Overall Symptom scale (GOS) was utilized to assess gastric discomfort before and after deprescribing. From 745 patients recruited, 226 (30.33%) were classified under “potentially inappropriate”, out of which 113 (15.16%) were deprescribed. When paired t-test was applied, GOS scale indicated significant difference in symptoms before and after deprescribing (P- value<0.01). Deprescribing of PPI decreased the incidence of long-term ADR, cost burden and promotes healthy lifestyle therefore, may help improving Quality of Life (Q0L).https://www.ojhas.org/issue78/2021-2-4.htmlproton pump inhibitorsdeprescribingadverse drug reactionsquality of life |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Apoorva Rachana Kulkarni Harsha Prakash Nair Eswaran Maheswari Avinash Balekuduru Ganesan Rajalekshmi Saraswathy Ann Mary Swaroop |
spellingShingle |
Apoorva Rachana Kulkarni Harsha Prakash Nair Eswaran Maheswari Avinash Balekuduru Ganesan Rajalekshmi Saraswathy Ann Mary Swaroop Deprescribing of Inappropriately Consumed Proton Pump Inhibitors and its Clinical Consequences Online Journal of Health & Allied Sciences proton pump inhibitors deprescribing adverse drug reactions quality of life |
author_facet |
Apoorva Rachana Kulkarni Harsha Prakash Nair Eswaran Maheswari Avinash Balekuduru Ganesan Rajalekshmi Saraswathy Ann Mary Swaroop |
author_sort |
Apoorva Rachana Kulkarni |
title |
Deprescribing of Inappropriately Consumed Proton Pump Inhibitors and its Clinical Consequences |
title_short |
Deprescribing of Inappropriately Consumed Proton Pump Inhibitors and its Clinical Consequences |
title_full |
Deprescribing of Inappropriately Consumed Proton Pump Inhibitors and its Clinical Consequences |
title_fullStr |
Deprescribing of Inappropriately Consumed Proton Pump Inhibitors and its Clinical Consequences |
title_full_unstemmed |
Deprescribing of Inappropriately Consumed Proton Pump Inhibitors and its Clinical Consequences |
title_sort |
deprescribing of inappropriately consumed proton pump inhibitors and its clinical consequences |
publisher |
Light House Polyclinic Mangalore |
series |
Online Journal of Health & Allied Sciences |
issn |
0972-5997 |
publishDate |
2021-08-01 |
description |
The study aimed to deprescribe inappropriate consumption among Proton Pump Inhibitor (PPI) users and assess the clinical consequences of deprescribing. This is a prospective interventional study carried out among patients aged >18 years and consuming PPI. The “potentially inappropriate” patients were counselled on harms of inappropriate PPI usage, impact of healthy dietary and lifestyle habits employing a Patient Information Leaflet (PIL). The patients deprescribed were followed up through telephonic communication. Global Overall Symptom scale (GOS) was utilized to assess gastric discomfort before and after deprescribing. From 745 patients recruited, 226 (30.33%) were classified under “potentially inappropriate”, out of which 113 (15.16%) were deprescribed. When paired t-test was applied, GOS scale indicated significant difference in symptoms before and after deprescribing (P- value<0.01). Deprescribing of PPI decreased the incidence of long-term ADR, cost burden and promotes healthy lifestyle therefore, may help improving Quality of Life (Q0L). |
topic |
proton pump inhibitors deprescribing adverse drug reactions quality of life |
url |
https://www.ojhas.org/issue78/2021-2-4.html |
work_keys_str_mv |
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