Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra
Rap, a member of the Ras-like small G-protein family, is a key node among G-protein coupled receptors (GPCR), receptor tyrosine kinases (RTKs), ion channels and many other downstream pathways. Rap plays a unique role in cell morphogenesis, adhesion, migration, exocytosis, proliferation, apoptosis an...
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Cell Physiol Biochem Press GmbH & Co KG
2016-06-01
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doaj-19ec53fc154d439ab8562bd60b9ff5d02020-11-25T01:37:49ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782016-06-0139113715610.1159/000445612445612Rap-Interacting Proteins are Key Players in the Rap Symphony OrchestraXiao-Xi GuoSu AnYang YangYing LiuQian HaoTian-Rui XuRap, a member of the Ras-like small G-protein family, is a key node among G-protein coupled receptors (GPCR), receptor tyrosine kinases (RTKs), ion channels and many other downstream pathways. Rap plays a unique role in cell morphogenesis, adhesion, migration, exocytosis, proliferation, apoptosis and carcinogenesis. The complexity and diversity of Rap functions are tightly regulated by Rap-interacting proteins such as GEFs, GAPs, Rap effectors and scaffold proteins. These interacting proteins decide the subcellular localization of Rap, the interaction modes with downstream Rap effectors and tune Rap as an atypical molecular conductor, coupling extra- and intracellular signals to various pathways. In this review, we summarize four groups of Rap-interacting proteins, highlight their distinctions in Rap-binding properties and interactive modes and discuss their contribution to the spatiotemporal regulation of Rap as well as the implications of targeting Rap-interacting proteins in human cancer therapy.http://www.karger.com/Article/FullText/445612CancerCell adhesionCell migrationSmall G-proteins |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiao-Xi Guo Su An Yang Yang Ying Liu Qian Hao Tian-Rui Xu |
spellingShingle |
Xiao-Xi Guo Su An Yang Yang Ying Liu Qian Hao Tian-Rui Xu Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra Cellular Physiology and Biochemistry Cancer Cell adhesion Cell migration Small G-proteins |
author_facet |
Xiao-Xi Guo Su An Yang Yang Ying Liu Qian Hao Tian-Rui Xu |
author_sort |
Xiao-Xi Guo |
title |
Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra |
title_short |
Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra |
title_full |
Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra |
title_fullStr |
Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra |
title_full_unstemmed |
Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra |
title_sort |
rap-interacting proteins are key players in the rap symphony orchestra |
publisher |
Cell Physiol Biochem Press GmbH & Co KG |
series |
Cellular Physiology and Biochemistry |
issn |
1015-8987 1421-9778 |
publishDate |
2016-06-01 |
description |
Rap, a member of the Ras-like small G-protein family, is a key node among G-protein coupled receptors (GPCR), receptor tyrosine kinases (RTKs), ion channels and many other downstream pathways. Rap plays a unique role in cell morphogenesis, adhesion, migration, exocytosis, proliferation, apoptosis and carcinogenesis. The complexity and diversity of Rap functions are tightly regulated by Rap-interacting proteins such as GEFs, GAPs, Rap effectors and scaffold proteins. These interacting proteins decide the subcellular localization of Rap, the interaction modes with downstream Rap effectors and tune Rap as an atypical molecular conductor, coupling extra- and intracellular signals to various pathways. In this review, we summarize four groups of Rap-interacting proteins, highlight their distinctions in Rap-binding properties and interactive modes and discuss their contribution to the spatiotemporal regulation of Rap as well as the implications of targeting Rap-interacting proteins in human cancer therapy. |
topic |
Cancer Cell adhesion Cell migration Small G-proteins |
url |
http://www.karger.com/Article/FullText/445612 |
work_keys_str_mv |
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1725057213806936064 |