Histocytopathological Evaluation of Soft Tissue Tumours: A Retrospective Study
Introduction: Soft Tissue Tumours (STTs) are a heterogeneous group of lesions arising from non-epithelial extraskeletal tissue of the body. The use of Fine Needle Aspiration Cytology (FNAC) in the evaluation of STTs is debatable because of their extremely varied morphology. Aim: To assess the ef...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2021-07-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2489/48487_CE[Ra1]_F(SHU)_PF1(AG_SHU)_PFA(KM)_PB(AG_KM)_PN(KM).pdf |
| Summary: | Introduction: Soft Tissue Tumours (STTs) are a heterogeneous group
of lesions arising from non-epithelial extraskeletal tissue of the body.
The use of Fine Needle Aspiration Cytology (FNAC) in the evaluation
of STTs is debatable because of their extremely varied morphology.
Aim: To assess the efficacy of FNAC in the diagnosis of STTs as
a routine procedure.
Materials and Methods: The present study was a retrospective
study conducted at VSS Institute of Medical Science and
Research, Burla, Sambalpur, Odisha, India, from December 2016
to November 2018. A total of 186 cases of STT were correlated
with histopathological studies. Fine needle aspirate air-dried
smears were stained with Diff-Quik and 95% alcohol fixed smears
were stained with Papanicolaou (PAP) stain. Corresponding
histopathological sections were stained with Haematoxylin and
Eosin (H&E) stain. Immunostaining was performed as and when
required to confirm histological diagnosis. Results were analysed
using International Business Machines (IBM) Statistical Package
for the Social Sciences (SPSS) Statistics 22.0.
Results: Out of 186 cases, 162 (87.09%) were diagnosed as
benign and 24 (12.91%) as malignant. Three false negative and
two false positive cases were reported. The sensitivity, specificity,
Positive Predictive Values (PPV), Negative Predictive Values
(NPV) and overall diagnostic accuracy were 87.5%, 98.7%,
91.3%, 98.1% and 97.3%, respectively. There was statistically
significant difference between the cytological diagnosis and the
final histological diagnosis (χ2
=35.5, p<0.05).
Conclusion: Fine Needle Aspiration (FNA) is very important for
initial diagnostic work-up, while histopathology with the help of
immunostain provides a final diagnosis. |
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| ISSN: | 2277-8551 2455-6882 |