Enhanced Bone Marrow Homing of Natural Killer Cells Following mRNA Transfection With Gain-of-Function Variant CXCR4R334X

Enhanced Bone Marrow Homing of Natural Killer Cells Following mRNA Transfection With Gain-of-Function Variant CXCR4R334X

Adoptive transfer of natural killer (NK) cells can induce remission in patients with relapsed/refractory leukemia and myeloma. However, to date, clinical efficacy of NK cell immunotherapy has been limited to a sub-fraction of patients. Here we show that steps incorporated in the ex vivo manipulation...

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Bibliographic Details
Main Authors: Emily Levy, Robert Reger, Filip Segerberg, Melanie Lambert, Caroline Leijonhufvud, Yvonne Baumer, Mattias Carlsten, Richard Childs
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
NK cells
homing
mRNA transfection
CXCR4
immunotherapy
WHIM
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01262/full

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