The pure effects of occurrence relapse on fatigue and quality of life in patients with multiple sclerosis: A post hoc analysis with high statistical control
Introduction: Relapses are the most obvious clinical feature of multiple sclerosis (MS) that can have different effects on patients fatigue and quality of life. Therefore, the aim of present study was to evaluate pure effects of occurrence relapse on fatigue and quality of life in patients with MS....
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Neyshabur University of Medical Sciences
2018-11-01
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doaj-1a001fdead174f4dadd22c2110fe83722020-11-25T02:07:59ZfasNeyshabur University of Medical SciencesMajallah-i Dānishkadah-i ̒ulūm-i Pizishkī-i Niyshābūr2383-32032476-27682018-11-01632637The pure effects of occurrence relapse on fatigue and quality of life in patients with multiple sclerosis: A post hoc analysis with high statistical controlGHASEM salehpoor0Javad Molazade1 Shiraz University Shiraz University Introduction: Relapses are the most obvious clinical feature of multiple sclerosis (MS) that can have different effects on patients fatigue and quality of life. Therefore, the aim of present study was to evaluate pure effects of occurrence relapse on fatigue and quality of life in patients with MS. Materials and Methods: In a cross-sectional study, 162 patients with MS (in three groups: non-relapse, 1-2 times of relapses, and ≥ 3 times of relapses) were selected by consecutive sampling and using the clinical and demographic variables inventory, the Health Survey questionnaire (SF-36) and Fatigue Severity Scale (FSS) along with identical analog-spring balance were examined. The data were analyzed byChi-square test, one-way analysis of variance (ANOVA), multivariate analysis of variance (MANOVA), multivariate analysis of covariance (MANCOVA), and post hoc tests of Fisher least significant difference (LSD) and Scheffe. Results: The adjusted analyses showed that effects of occurrence relapse was significant in physical functioning, vitality, social functioning, mental health, and physical and mental components (P < 0.05). The following of difference between means in relapse groups showed that patients with ≥3 times of relapses in all identified significant variables have lower mean scores (P < 0.05). In the meantime, significant differences were not observed between different groups of relapse in terms of fatigue level (P > 0.05). Conclusion: MS relapses leading to reduced quality of life in patients and its effects in patients with high relapse rate is highlight.http://journal.nums.ac.ir/browse.php?a_code=A-10-735-1&slc_lang=en&sid=1Multiple SclerosisRelapseQuality of LifeFatigue |
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language |
fas |
format |
Article |
sources |
DOAJ |
author |
GHASEM salehpoor Javad Molazade |
spellingShingle |
GHASEM salehpoor Javad Molazade The pure effects of occurrence relapse on fatigue and quality of life in patients with multiple sclerosis: A post hoc analysis with high statistical control Majallah-i Dānishkadah-i ̒ulūm-i Pizishkī-i Niyshābūr Multiple Sclerosis Relapse Quality of Life Fatigue |
author_facet |
GHASEM salehpoor Javad Molazade |
author_sort |
GHASEM salehpoor |
title |
The pure effects of occurrence relapse on fatigue and quality of life in patients with multiple sclerosis: A post hoc analysis with high statistical control |
title_short |
The pure effects of occurrence relapse on fatigue and quality of life in patients with multiple sclerosis: A post hoc analysis with high statistical control |
title_full |
The pure effects of occurrence relapse on fatigue and quality of life in patients with multiple sclerosis: A post hoc analysis with high statistical control |
title_fullStr |
The pure effects of occurrence relapse on fatigue and quality of life in patients with multiple sclerosis: A post hoc analysis with high statistical control |
title_full_unstemmed |
The pure effects of occurrence relapse on fatigue and quality of life in patients with multiple sclerosis: A post hoc analysis with high statistical control |
title_sort |
pure effects of occurrence relapse on fatigue and quality of life in patients with multiple sclerosis: a post hoc analysis with high statistical control |
publisher |
Neyshabur University of Medical Sciences |
series |
Majallah-i Dānishkadah-i ̒ulūm-i Pizishkī-i Niyshābūr |
issn |
2383-3203 2476-2768 |
publishDate |
2018-11-01 |
description |
Introduction: Relapses are the most obvious clinical feature of multiple sclerosis (MS) that can have different effects on patients fatigue and quality of life. Therefore, the aim of present study was to evaluate pure effects of occurrence relapse on fatigue and quality of life in patients with MS.
Materials and Methods: In a cross-sectional study, 162 patients with MS (in three groups: non-relapse, 1-2 times of relapses, and ≥ 3 times of relapses) were selected by consecutive sampling and using the clinical and demographic variables inventory, the Health Survey questionnaire (SF-36) and Fatigue Severity Scale (FSS) along with identical analog-spring balance were examined. The data were analyzed byChi-square test, one-way analysis of variance (ANOVA), multivariate analysis of variance (MANOVA), multivariate analysis of covariance (MANCOVA), and post hoc tests of Fisher least significant difference (LSD) and Scheffe.
Results: The adjusted analyses showed that effects of occurrence relapse was significant in physical functioning, vitality, social functioning, mental health, and physical and mental components (P < 0.05). The following of difference between means in relapse groups showed that patients with ≥3 times of relapses in all identified significant variables have lower mean scores (P < 0.05). In the meantime, significant differences were not observed between different groups of relapse in terms of fatigue level (P > 0.05).
Conclusion: MS relapses leading to reduced quality of life in patients and its effects in patients with high relapse rate is highlight. |
topic |
Multiple Sclerosis Relapse Quality of Life Fatigue |
url |
http://journal.nums.ac.ir/browse.php?a_code=A-10-735-1&slc_lang=en&sid=1 |
work_keys_str_mv |
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