Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

Abstract Background Cell-to-cell propagation of α-synuclein (α-syn) aggregates is thought to contribute to the pathogenesis of Parkinson’s disease (PD) and underlie the spread of α-syn neuropathology. Increased pro-inflammatory cytokine levels and activated microglia are present in PD and activated...

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Bibliographic Details
Main Authors: Sonia George, Nolwen L. Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, Emily Schulz, Steven Pierce, Amanda R. Burmeister, Zachary Madaj, Jennifer A. Steiner, Martha L. Escobar Galvis, Lena Brundin, Patrik Brundin
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
Alpha-synuclein
Prion-like
Microglia
Lipopolysaccharide
Interleukin-4
Online Access:http://link.springer.com/article/10.1186/s13024-019-0335-3

Internet

http://link.springer.com/article/10.1186/s13024-019-0335-3

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