Small intestinal taurochenodeoxycholic acid-FXR axis alters local nutrient-sensing glucoregulatory pathways in rats

Small intestinal taurochenodeoxycholic acid-FXR axis alters local nutrient-sensing glucoregulatory pathways in rats

Objective: The mechanism of nutrient sensing in the upper small intestine (USI) and ileum that regulates glucose homeostasis remains elusive. Short-term high-fat (HF) feeding increases taurochenodeoxycholic acid (TCDCA; an agonist of farnesoid X receptor (FXR)) in the USI and ileum of rats, and the...

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Bibliographic Details
Main Authors:	T.M. Zaved Waise, Yu-Mi Lim, Zahra Danaei, Song-Yang Zhang, Tony K.T. Lam
Format:	Article
Language:	English
Published:	Elsevier 2021-02-01
Series:	Molecular Metabolism
Subjects:	Small intestine Nutrient sensing Glucose tolerance Bile acids FXR
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877820302064

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