<b>Characterization and qualification of diclofenac sodium as a secondary standard</b> - doi: 10.4025/actascitechnol.v34i1.11654

<b>Characterization and qualification of diclofenac sodium as a secondary standard</b> - doi: 10.4025/actascitechnol.v34i1.11654

<p class="aresumo">This paper aimed to characterize and qualify a secondary standard of diclofenac sodium as a reference standard in the quality control of medicines. The identity of the candidate was confirmed through infrared spectroscopy and the content (99.63%) determined by high...

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Main Authors: Paulo Roberto Stoef, Silvane Guzzi, Marla Suzane Carletto, Viviane da Silva Lobo, Mauricio Ferreira da Rosa
Format: Article
Language:English
Published: Universidade Estadual de Maringá 2011-11-01
Series:Acta Scientiarum: Technology
Subjects:
espectroscopia de infravermelho
padrão de referência
CLAE
Online Access:http://periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/11654
id doaj-1a16b0922a7c420bbaee2332cd2b66b4
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spelling doaj-1a16b0922a7c420bbaee2332cd2b66b42020-11-25T01:45:01ZengUniversidade Estadual de MaringáActa Scientiarum: Technology1806-25631807-86642011-11-01341899510.4025/actascitechnol.v34i1.116546942<b>Characterization and qualification of diclofenac sodium as a secondary standard</b> - doi: 10.4025/actascitechnol.v34i1.11654Paulo Roberto Stoef0Silvane Guzzi1Marla Suzane Carletto2Viviane da Silva Lobo3Mauricio Ferreira da Rosa4Indústria Farmacêutica Prati-Donaduzzi & Companhia LtdaIndústria Farmacêutica Prati-Donaduzzi & Companhia LtdaIndústria Farmacêutica Prati-Donaduzzi & Companhia LtdaUniversidade Tecnológica Federal do ParanáUniversidade Estadual do Oeste do Paraná<p class="aresumo">This paper aimed to characterize and qualify a secondary standard of diclofenac sodium as a reference standard in the quality control of medicines. The identity of the candidate was confirmed through infrared spectroscopy and the content (99.63%) determined by high performance liquid chromatography (HPLC) by comparing with the compendial primary standard. The quality of the secondary standard was also supported by redox titration in non-aqueous media, related substances and UV spectrum by HPLC.</p><p class="akeyword"> </p>http://periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/11654espectroscopia de infravermelhopadrão de referênciaCLAE
collection DOAJ
language English
format Article
sources DOAJ
author Paulo Roberto Stoef
Silvane Guzzi
Marla Suzane Carletto
Viviane da Silva Lobo
Mauricio Ferreira da Rosa
spellingShingle Paulo Roberto Stoef
Silvane Guzzi
Marla Suzane Carletto
Viviane da Silva Lobo
Mauricio Ferreira da Rosa
<b>Characterization and qualification of diclofenac sodium as a secondary standard</b> - doi: 10.4025/actascitechnol.v34i1.11654
Acta Scientiarum: Technology
espectroscopia de infravermelho
padrão de referência
CLAE
author_facet Paulo Roberto Stoef
Silvane Guzzi
Marla Suzane Carletto
Viviane da Silva Lobo
Mauricio Ferreira da Rosa
author_sort Paulo Roberto Stoef
title <b>Characterization and qualification of diclofenac sodium as a secondary standard</b> - doi: 10.4025/actascitechnol.v34i1.11654
title_short <b>Characterization and qualification of diclofenac sodium as a secondary standard</b> - doi: 10.4025/actascitechnol.v34i1.11654
title_full <b>Characterization and qualification of diclofenac sodium as a secondary standard</b> - doi: 10.4025/actascitechnol.v34i1.11654
title_fullStr <b>Characterization and qualification of diclofenac sodium as a secondary standard</b> - doi: 10.4025/actascitechnol.v34i1.11654
title_full_unstemmed <b>Characterization and qualification of diclofenac sodium as a secondary standard</b> - doi: 10.4025/actascitechnol.v34i1.11654
title_sort <b>characterization and qualification of diclofenac sodium as a secondary standard</b> - doi: 10.4025/actascitechnol.v34i1.11654
publisher Universidade Estadual de Maringá
series Acta Scientiarum: Technology
issn 1806-2563
1807-8664
publishDate 2011-11-01
description <p class="aresumo">This paper aimed to characterize and qualify a secondary standard of diclofenac sodium as a reference standard in the quality control of medicines. The identity of the candidate was confirmed through infrared spectroscopy and the content (99.63%) determined by high performance liquid chromatography (HPLC) by comparing with the compendial primary standard. The quality of the secondary standard was also supported by redox titration in non-aqueous media, related substances and UV spectrum by HPLC.</p><p class="akeyword"> </p>
topic espectroscopia de infravermelho
padrão de referência
CLAE
url http://periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/11654
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