Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase

Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase

Proteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown. We have previously shown that Tctex-1 (or DYNLT1) can interact with the parathyroid hormo...

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Main Authors: Masaki Saito, Ayano Chiba, Takeya Sato, Takahiro Moriya, Jun Sukegawa, Norimichi Nakahata
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Pharmacological Sciences
Subjects:
Cytoplasmic dynein light chain Tctex-1
Parathyroid hormone receptor
Adenylyl cyclase
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320301171
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spelling doaj-1a1a07cb952649b0911e458a135210102020-12-25T05:07:20ZengElsevierJournal of Pharmacological Sciences1347-86132021-01-011451150154Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclaseMasaki Saito0Ayano Chiba1Takeya Sato2Takahiro Moriya3Jun Sukegawa4Norimichi Nakahata5Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan; Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan; Corresponding author. Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai, 980-8575, Japan. Fax: +81 (22) 717 8065.Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, JapanDepartment of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, JapanDepartment of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, JapanDepartment of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan; Department of Human Health and Nutrition, Shokei Gakuin University, Natori, 981-1295, JapanDepartment of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, JapanProteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown. We have previously shown that Tctex-1 (or DYNLT1) can interact with the parathyroid hormone receptor (PTHR). In the present study, we investigated the role of Tctex-1 in the PTHR signaling and found that Tctex-1 augmented the PTHR-mediated Gs/adenylyl cyclase (AC) pathway by activating AC regardless of the binding to PTHR. Furthermore, Tctex-1 directly bound to AC type 6. These data demonstrate a novel mechanism underlying GPCR/Gs signaling regulated by Tctex-1.http://www.sciencedirect.com/science/article/pii/S1347861320301171Cytoplasmic dynein light chain Tctex-1Parathyroid hormone receptorAdenylyl cyclase
collection DOAJ
language English
format Article
sources DOAJ
author Masaki Saito
Ayano Chiba
Takeya Sato
Takahiro Moriya
Jun Sukegawa
Norimichi Nakahata
spellingShingle Masaki Saito
Ayano Chiba
Takeya Sato
Takahiro Moriya
Jun Sukegawa
Norimichi Nakahata
Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase
Journal of Pharmacological Sciences
Cytoplasmic dynein light chain Tctex-1
Parathyroid hormone receptor
Adenylyl cyclase
author_facet Masaki Saito
Ayano Chiba
Takeya Sato
Takahiro Moriya
Jun Sukegawa
Norimichi Nakahata
author_sort Masaki Saito
title Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase
title_short Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase
title_full Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase
title_fullStr Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase
title_full_unstemmed Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase
title_sort tctex-1 augments g protein-coupled receptor-mediated gs signaling by activating adenylyl cyclase
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2021-01-01
description Proteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown. We have previously shown that Tctex-1 (or DYNLT1) can interact with the parathyroid hormone receptor (PTHR). In the present study, we investigated the role of Tctex-1 in the PTHR signaling and found that Tctex-1 augmented the PTHR-mediated Gs/adenylyl cyclase (AC) pathway by activating AC regardless of the binding to PTHR. Furthermore, Tctex-1 directly bound to AC type 6. These data demonstrate a novel mechanism underlying GPCR/Gs signaling regulated by Tctex-1.
topic Cytoplasmic dynein light chain Tctex-1
Parathyroid hormone receptor
Adenylyl cyclase
url http://www.sciencedirect.com/science/article/pii/S1347861320301171
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