Comprehensive Profiling of Primary and Metastatic ccRCC Reveals a High Homology of the Metastases to a Subregion of the Primary Tumour

Comprehensive Profiling of Primary and Metastatic ccRCC Reveals a High Homology of the Metastases to a Subregion of the Primary Tumour

While intratumour genetic heterogeneity of primary clear cell renal cell carcinoma (ccRCC) is well characterized, the genomic profiles of metastatic ccRCCs are seldom studied. We profiled the genomes and transcriptomes of a primary tumour and matched metastases to better understand the evolutionary...

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Bibliographic Details
Main Authors: Paranita Ferronika, Joost Hof, Gursah Kats-Ugurlu, Rolf H. Sijmons, Martijn M. Terpstra, Kim de Lange, Annemarie Leliveld-Kors, Helga Westers, Klaas Kok
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
intratumour heterogeneity
metastatic ccRCC
copy number alteration
mutation
gene expression
Online Access:https://www.mdpi.com/2072-6694/11/6/812

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