Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study.
To evaluate the utility of urine protein/creatinine ratio (uPCR) measurements among healthy parturients at term we performed a prospective cohort study at a community teaching hospital.Serial urine samples were collected. Ninety-three women contributed 284 urine samples. uPCRs were determined. Multi...
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doaj-1a22169098de4c5a8cf8b106833b077e2020-11-24T21:47:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01118e016045310.1371/journal.pone.0160453Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study.Vaya W TanamaiBrandon-Luke L SeagleJudy Y YehBethany BradyCorrie B MillerSalvador SenaJessica DodgeShohreh ShahabiRobert SamuelsonErrol R NorwitzGuoyang LuoTo evaluate the utility of urine protein/creatinine ratio (uPCR) measurements among healthy parturients at term we performed a prospective cohort study at a community teaching hospital.Serial urine samples were collected. Ninety-three women contributed 284 urine samples. uPCRs were determined. Multiple imputation and paired sampled analysis was performed when appropriate.Two-thirds (63/93) of women had at least one measured uPCR ≥ 0.3. One-third (31/93) had a uPCR ≥ 0.3 at admission, including 39.1% (9/23) of women not in labor. Median (IQR) uPCRs increased during labor and after delivery: latent phase/no labor, 0.15 (0.06-0.32); active phase, 0.29 (0.10-0.58); early postpartum, 0.45 (0.18-1.36) (all p < 0.04). Median uPCRs were significantly < 0.3 in the latent phase and significantly > 0.3 in the immediate postpartum period (p < 0.01). Women who labored before cesarean delivery had the highest early postpartum uPCRs: median (IQR) 1.16 (0.39-1.80). A negative urine dipstick protein result did not exclude uPCR ≥ 0.3. uPCRs were similar when compared by method of urine collection.uPCR ≥ 0.3 is common among healthy women with uncomplicated pregnancies at term. uPCR increases during labor and is not a reliable measure of pathologic proteinuria at term or during the peripartum period.http://europepmc.org/articles/PMC4968820?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vaya W Tanamai Brandon-Luke L Seagle Judy Y Yeh Bethany Brady Corrie B Miller Salvador Sena Jessica Dodge Shohreh Shahabi Robert Samuelson Errol R Norwitz Guoyang Luo |
spellingShingle |
Vaya W Tanamai Brandon-Luke L Seagle Judy Y Yeh Bethany Brady Corrie B Miller Salvador Sena Jessica Dodge Shohreh Shahabi Robert Samuelson Errol R Norwitz Guoyang Luo Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study. PLoS ONE |
author_facet |
Vaya W Tanamai Brandon-Luke L Seagle Judy Y Yeh Bethany Brady Corrie B Miller Salvador Sena Jessica Dodge Shohreh Shahabi Robert Samuelson Errol R Norwitz Guoyang Luo |
author_sort |
Vaya W Tanamai |
title |
Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study. |
title_short |
Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study. |
title_full |
Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study. |
title_fullStr |
Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study. |
title_full_unstemmed |
Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study. |
title_sort |
urine protein/creatinine ratios during labor: a prospective observational study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
To evaluate the utility of urine protein/creatinine ratio (uPCR) measurements among healthy parturients at term we performed a prospective cohort study at a community teaching hospital.Serial urine samples were collected. Ninety-three women contributed 284 urine samples. uPCRs were determined. Multiple imputation and paired sampled analysis was performed when appropriate.Two-thirds (63/93) of women had at least one measured uPCR ≥ 0.3. One-third (31/93) had a uPCR ≥ 0.3 at admission, including 39.1% (9/23) of women not in labor. Median (IQR) uPCRs increased during labor and after delivery: latent phase/no labor, 0.15 (0.06-0.32); active phase, 0.29 (0.10-0.58); early postpartum, 0.45 (0.18-1.36) (all p < 0.04). Median uPCRs were significantly < 0.3 in the latent phase and significantly > 0.3 in the immediate postpartum period (p < 0.01). Women who labored before cesarean delivery had the highest early postpartum uPCRs: median (IQR) 1.16 (0.39-1.80). A negative urine dipstick protein result did not exclude uPCR ≥ 0.3. uPCRs were similar when compared by method of urine collection.uPCR ≥ 0.3 is common among healthy women with uncomplicated pregnancies at term. uPCR increases during labor and is not a reliable measure of pathologic proteinuria at term or during the peripartum period. |
url |
http://europepmc.org/articles/PMC4968820?pdf=render |
work_keys_str_mv |
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