Clinical prevalence of Lewy body dementia
Abstract Background The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson’s disease (PDD) in routine clinical practice is unclear. Prevalence rates observed in clinical and population-based cohorts and neuropathological studies vary greatly. Small sample sizes and methodologica...
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doaj-1a25d6ae02c7481ca1be6c6136d9bcd12020-11-25T02:18:37ZengBMCAlzheimer’s Research & Therapy1758-91932018-02-011011810.1186/s13195-018-0350-6Clinical prevalence of Lewy body dementiaJoseph P. M. Kane0Ajenthan Surendranathan1Allison Bentley2Sally A. H. Barker3John-Paul Taylor4Alan J. Thomas5Louise M. Allan6Richard J. McNally7Peter W. James8Ian G. McKeith9David J. Burn10John T. O’Brien11Institute of Neuroscience, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle UniversityDepartment of Psychiatry, University of Cambridge School of Clinical MedicineDepartment of Psychiatry, University of Cambridge School of Clinical MedicineInstitute of Neuroscience, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle UniversityInstitute of Neuroscience, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle UniversityInstitute of Neuroscience, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle UniversityInstitute of Neuroscience, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle UniversityInstitute of Health and Society, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle UniversityInstitute of Health and Society, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle UniversityInstitute of Neuroscience, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle UniversityInstitute of Neuroscience, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle UniversityInstitute of Neuroscience, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle UniversityAbstract Background The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson’s disease (PDD) in routine clinical practice is unclear. Prevalence rates observed in clinical and population-based cohorts and neuropathological studies vary greatly. Small sample sizes and methodological factors in these studies limit generalisability to clinical practice. Methods We investigated prevalence in a case series across nine secondary care services over an 18-month period, to determine how commonly DLB and PDD cases are diagnosed and reviewed within two regions of the UK. Results Patients with DLB comprised 4.6% (95% CI 4.0–5.2%) of all dementia cases. DLB was represented in a significantly higher proportion of dementia cases in services in the North East (5.6%) than those in East Anglia (3.3%; χ2 = 13.6, p < 0.01). DLB prevalence in individual services ranged from 2.4 to 5.9%. PDD comprised 9.7% (95% CI 8.3–11.1%) of Parkinson’s disease cases. No significant variation in PDD prevalence was observed between regions or between services. Conclusions We found that the frequency of clinical diagnosis of DLB varied between geographical regions in the UK, and that the prevalence of both DLB and PDD was much lower than would be expected in this case series, suggesting considerable under-diagnosis of both disorders. The significant variation in DLB diagnostic rates between these two regions may reflect true differences in disease prevalence, but more likely differences in diagnostic practice. The systematic introduction of more standardised diagnostic practice could improve the rates of diagnosis of both conditions.http://link.springer.com/article/10.1186/s13195-018-0350-6Dementia with Lewy bodiesDementia in Parkinson’s diseaseEpidemiologyPrevalence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joseph P. M. Kane Ajenthan Surendranathan Allison Bentley Sally A. H. Barker John-Paul Taylor Alan J. Thomas Louise M. Allan Richard J. McNally Peter W. James Ian G. McKeith David J. Burn John T. O’Brien |
spellingShingle |
Joseph P. M. Kane Ajenthan Surendranathan Allison Bentley Sally A. H. Barker John-Paul Taylor Alan J. Thomas Louise M. Allan Richard J. McNally Peter W. James Ian G. McKeith David J. Burn John T. O’Brien Clinical prevalence of Lewy body dementia Alzheimer’s Research & Therapy Dementia with Lewy bodies Dementia in Parkinson’s disease Epidemiology Prevalence |
author_facet |
Joseph P. M. Kane Ajenthan Surendranathan Allison Bentley Sally A. H. Barker John-Paul Taylor Alan J. Thomas Louise M. Allan Richard J. McNally Peter W. James Ian G. McKeith David J. Burn John T. O’Brien |
author_sort |
Joseph P. M. Kane |
title |
Clinical prevalence of Lewy body dementia |
title_short |
Clinical prevalence of Lewy body dementia |
title_full |
Clinical prevalence of Lewy body dementia |
title_fullStr |
Clinical prevalence of Lewy body dementia |
title_full_unstemmed |
Clinical prevalence of Lewy body dementia |
title_sort |
clinical prevalence of lewy body dementia |
publisher |
BMC |
series |
Alzheimer’s Research & Therapy |
issn |
1758-9193 |
publishDate |
2018-02-01 |
description |
Abstract Background The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson’s disease (PDD) in routine clinical practice is unclear. Prevalence rates observed in clinical and population-based cohorts and neuropathological studies vary greatly. Small sample sizes and methodological factors in these studies limit generalisability to clinical practice. Methods We investigated prevalence in a case series across nine secondary care services over an 18-month period, to determine how commonly DLB and PDD cases are diagnosed and reviewed within two regions of the UK. Results Patients with DLB comprised 4.6% (95% CI 4.0–5.2%) of all dementia cases. DLB was represented in a significantly higher proportion of dementia cases in services in the North East (5.6%) than those in East Anglia (3.3%; χ2 = 13.6, p < 0.01). DLB prevalence in individual services ranged from 2.4 to 5.9%. PDD comprised 9.7% (95% CI 8.3–11.1%) of Parkinson’s disease cases. No significant variation in PDD prevalence was observed between regions or between services. Conclusions We found that the frequency of clinical diagnosis of DLB varied between geographical regions in the UK, and that the prevalence of both DLB and PDD was much lower than would be expected in this case series, suggesting considerable under-diagnosis of both disorders. The significant variation in DLB diagnostic rates between these two regions may reflect true differences in disease prevalence, but more likely differences in diagnostic practice. The systematic introduction of more standardised diagnostic practice could improve the rates of diagnosis of both conditions. |
topic |
Dementia with Lewy bodies Dementia in Parkinson’s disease Epidemiology Prevalence |
url |
http://link.springer.com/article/10.1186/s13195-018-0350-6 |
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