“Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report

Chronic myelogenous leukemia (CML), in the Chronic Phase (CP), is often suspected as a result of a complete blood count (CBC), which shows increased granulocytes, mostly mature including a peak in myelocytes, increased basophils, and rarely blasts and/or promyelocytes. Morphologic dysplasia is not p...

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Main Authors: John M. Bennett, Kevin G. Dsouza, Mehul Patel, Kristen O’Dwyer
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Leukemia Research Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048914200124
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spelling doaj-1a3335d4354c4ad193bc4d5dbf828b8c2020-11-24T23:47:00ZengElsevierLeukemia Research Reports2213-04892015-01-0141121410.1016/j.lrr.2014.12.002“Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case reportJohn M. Bennett0Kevin G. Dsouza1Mehul Patel2Kristen O’Dwyer3Department of Pathology, Medicine and James P. Wilmot Cancer Institute, Rochester, NY, USADepartment of Medicine, Hematology/Oncology Section, Rochester General Hospital, Rochester, NY, USADepartment of Medicine, Hematology/Oncology Section, Rochester General Hospital, Rochester, NY, USADepartment of Medicine and James P. Wilmot Cancer Institute, Rochester, NY, USAChronic myelogenous leukemia (CML), in the Chronic Phase (CP), is often suspected as a result of a complete blood count (CBC), which shows increased granulocytes, mostly mature including a peak in myelocytes, increased basophils, and rarely blasts and/or promyelocytes. Morphologic dysplasia is not present. CML is confirmed by detecting the characteristic Philadelphia chromosome (Ph)[t(9;22)(q34;q11.2)] by routine cytogenetics or fluorescent in situ hybridization (FISH) or molecular studies (RT-PCR) for the bcr-abl fusion gene. The most common feature of CML is an elevated WBC count, usually above 25×103/µL, and frequently above 100×103/µL. We report a case of confirmed Ph+CML with a normal CBC detected because of the presence of rare myelocytes and 2% basophils [Fig. 1]. Previous leukocyte counts for the preceding eight years were normal with the exception of one done four months prior to his presentation that showed an abnormal differential with 1% basophils, 2% metamyelocytes and 2% myelocytes.http://www.sciencedirect.com/science/article/pii/S2213048914200124Chronic myeloid leukemiaPhiladelphia chromosome
collection DOAJ
language English
format Article
sources DOAJ
author John M. Bennett
Kevin G. Dsouza
Mehul Patel
Kristen O’Dwyer
spellingShingle John M. Bennett
Kevin G. Dsouza
Mehul Patel
Kristen O’Dwyer
“Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report
Leukemia Research Reports
Chronic myeloid leukemia
Philadelphia chromosome
author_facet John M. Bennett
Kevin G. Dsouza
Mehul Patel
Kristen O’Dwyer
author_sort John M. Bennett
title “Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report
title_short “Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report
title_full “Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report
title_fullStr “Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report
title_full_unstemmed “Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report
title_sort “preleukemic or smoldering” chronic myelogenous leukemia (cml):bcr-abl1 positive: a brief case report
publisher Elsevier
series Leukemia Research Reports
issn 2213-0489
publishDate 2015-01-01
description Chronic myelogenous leukemia (CML), in the Chronic Phase (CP), is often suspected as a result of a complete blood count (CBC), which shows increased granulocytes, mostly mature including a peak in myelocytes, increased basophils, and rarely blasts and/or promyelocytes. Morphologic dysplasia is not present. CML is confirmed by detecting the characteristic Philadelphia chromosome (Ph)[t(9;22)(q34;q11.2)] by routine cytogenetics or fluorescent in situ hybridization (FISH) or molecular studies (RT-PCR) for the bcr-abl fusion gene. The most common feature of CML is an elevated WBC count, usually above 25×103/µL, and frequently above 100×103/µL. We report a case of confirmed Ph+CML with a normal CBC detected because of the presence of rare myelocytes and 2% basophils [Fig. 1]. Previous leukocyte counts for the preceding eight years were normal with the exception of one done four months prior to his presentation that showed an abnormal differential with 1% basophils, 2% metamyelocytes and 2% myelocytes.
topic Chronic myeloid leukemia
Philadelphia chromosome
url http://www.sciencedirect.com/science/article/pii/S2213048914200124
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