“Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report
Chronic myelogenous leukemia (CML), in the Chronic Phase (CP), is often suspected as a result of a complete blood count (CBC), which shows increased granulocytes, mostly mature including a peak in myelocytes, increased basophils, and rarely blasts and/or promyelocytes. Morphologic dysplasia is not p...
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doaj-1a3335d4354c4ad193bc4d5dbf828b8c2020-11-24T23:47:00ZengElsevierLeukemia Research Reports2213-04892015-01-0141121410.1016/j.lrr.2014.12.002“Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case reportJohn M. Bennett0Kevin G. Dsouza1Mehul Patel2Kristen O’Dwyer3Department of Pathology, Medicine and James P. Wilmot Cancer Institute, Rochester, NY, USADepartment of Medicine, Hematology/Oncology Section, Rochester General Hospital, Rochester, NY, USADepartment of Medicine, Hematology/Oncology Section, Rochester General Hospital, Rochester, NY, USADepartment of Medicine and James P. Wilmot Cancer Institute, Rochester, NY, USAChronic myelogenous leukemia (CML), in the Chronic Phase (CP), is often suspected as a result of a complete blood count (CBC), which shows increased granulocytes, mostly mature including a peak in myelocytes, increased basophils, and rarely blasts and/or promyelocytes. Morphologic dysplasia is not present. CML is confirmed by detecting the characteristic Philadelphia chromosome (Ph)[t(9;22)(q34;q11.2)] by routine cytogenetics or fluorescent in situ hybridization (FISH) or molecular studies (RT-PCR) for the bcr-abl fusion gene. The most common feature of CML is an elevated WBC count, usually above 25×103/µL, and frequently above 100×103/µL. We report a case of confirmed Ph+CML with a normal CBC detected because of the presence of rare myelocytes and 2% basophils [Fig. 1]. Previous leukocyte counts for the preceding eight years were normal with the exception of one done four months prior to his presentation that showed an abnormal differential with 1% basophils, 2% metamyelocytes and 2% myelocytes.http://www.sciencedirect.com/science/article/pii/S2213048914200124Chronic myeloid leukemiaPhiladelphia chromosome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
John M. Bennett Kevin G. Dsouza Mehul Patel Kristen O’Dwyer |
spellingShingle |
John M. Bennett Kevin G. Dsouza Mehul Patel Kristen O’Dwyer “Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report Leukemia Research Reports Chronic myeloid leukemia Philadelphia chromosome |
author_facet |
John M. Bennett Kevin G. Dsouza Mehul Patel Kristen O’Dwyer |
author_sort |
John M. Bennett |
title |
“Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report |
title_short |
“Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report |
title_full |
“Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report |
title_fullStr |
“Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report |
title_full_unstemmed |
“Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report |
title_sort |
“preleukemic or smoldering” chronic myelogenous leukemia (cml):bcr-abl1 positive: a brief case report |
publisher |
Elsevier |
series |
Leukemia Research Reports |
issn |
2213-0489 |
publishDate |
2015-01-01 |
description |
Chronic myelogenous leukemia (CML), in the Chronic Phase (CP), is often suspected as a result of a complete blood count (CBC), which shows increased granulocytes, mostly mature including a peak in myelocytes, increased basophils, and rarely blasts and/or promyelocytes. Morphologic dysplasia is not present. CML is confirmed by detecting the characteristic Philadelphia chromosome (Ph)[t(9;22)(q34;q11.2)] by routine cytogenetics or fluorescent in situ hybridization (FISH) or molecular studies (RT-PCR) for the bcr-abl fusion gene.
The most common feature of CML is an elevated WBC count, usually above 25×103/µL, and frequently above 100×103/µL. We report a case of confirmed Ph+CML with a normal CBC detected because of the presence of rare myelocytes and 2% basophils [Fig. 1]. Previous leukocyte counts for the preceding eight years were normal with the exception of one done four months prior to his presentation that showed an abnormal differential with 1% basophils, 2% metamyelocytes and 2% myelocytes. |
topic |
Chronic myeloid leukemia Philadelphia chromosome |
url |
http://www.sciencedirect.com/science/article/pii/S2213048914200124 |
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