Efficacy of intravitreal Ranibizumab injection for choroidal neovascularization secondary to pathologic myopia
AIM:To observe the efficacy and safety of intravitreal Ranibizumab injection in patiens with choroidal neovascularization(CNV)secondary to pathologic myopia.<p>METHODS:In this retrospective and comparative study,24 patients(25 eyes)with CNV secondary to pathologic myopia were enrolled. All pat...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2016-03-01
|
Series: | Guoji Yanke Zazhi |
Subjects: | |
Online Access: | http://ies.ijo.cn/cn_publish/2016/3/201603034.pdf |
id |
doaj-1a35d7ef59914d54b0c9a39bd606a48f |
---|---|
record_format |
Article |
spelling |
doaj-1a35d7ef59914d54b0c9a39bd606a48f2020-11-24T22:55:59ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232016-03-0116352652810.3980/j.issn.1672-5123.2016.3.34Efficacy of intravitreal Ranibizumab injection for choroidal neovascularization secondary to pathologic myopiaLi-Hong Cui0Zhi Yang1Li Xu2Department of Ophthalmology,Shenyang the Fourth Hospital of People, Shenyang 110031, Liaoning Province, ChinaDepartment of Ophthalmology,Shenyang the Fourth Hospital of People, Shenyang 110031, Liaoning Province, ChinaDepartment of Ophthalmology,Shenyang the Fourth Hospital of People, Shenyang 110031, Liaoning Province, ChinaAIM:To observe the efficacy and safety of intravitreal Ranibizumab injection in patiens with choroidal neovascularization(CNV)secondary to pathologic myopia.<p>METHODS:In this retrospective and comparative study,24 patients(25 eyes)with CNV secondary to pathologic myopia were enrolled. All patients were assessed by examinations of ETDRS visual acuity chart, preplaced-mirror ophthalmoscopy, fundus fluorescein angiography(FFA), indocyanine green angiography(ICGA)and optical coherence tomography(OCT). Patiens received intravitreally injected ranibizumab 0.5mg(0.05mL). Treatments were repeated if the follow-up indicated that it was necessary. The follow-up periods were 4~10mo. Best corrected visual acuity(BCVA), central macular thickness(CMT)and leakage of CNV before and after the treatment were compared. <p>RESULTS:No local or systemic complications occurred in any patients during the treatment or follow-up. The average time of injection was 1.52. The mean BCVA was 23.93±12.46 letters before the therapy. In the last follow-up, the mean BCVA was 40.63±7.25 letters, improved by 14.27±9.36 letters and the difference was statically significant(<i>t</i>=5.74, <i>P</i><0.05). The mean CMT was 363.47±119.62μm before treatments and 190.31±37.02μm after treatments which was 72.82±60.57 μm less than the pre-treatment values and the difference was statically significant(<i>t</i>=3.96, <i>P</i><0.05). <p>CONCLUSION:Intravitreal ranibizumab injection for CNV secondary to pathologic myopia is safe and effective, and this treatment can improve visual acuity, reduce retina edema and leakage of CNV.http://ies.ijo.cn/cn_publish/2016/3/201603034.pdfchoroidal neovascularizationdrug therapymyopiadegenerativeantibodiesmonoclonal |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li-Hong Cui Zhi Yang Li Xu |
spellingShingle |
Li-Hong Cui Zhi Yang Li Xu Efficacy of intravitreal Ranibizumab injection for choroidal neovascularization secondary to pathologic myopia Guoji Yanke Zazhi choroidal neovascularization drug therapy myopia degenerative antibodies monoclonal |
author_facet |
Li-Hong Cui Zhi Yang Li Xu |
author_sort |
Li-Hong Cui |
title |
Efficacy of intravitreal Ranibizumab injection for choroidal neovascularization secondary to pathologic myopia |
title_short |
Efficacy of intravitreal Ranibizumab injection for choroidal neovascularization secondary to pathologic myopia |
title_full |
Efficacy of intravitreal Ranibizumab injection for choroidal neovascularization secondary to pathologic myopia |
title_fullStr |
Efficacy of intravitreal Ranibizumab injection for choroidal neovascularization secondary to pathologic myopia |
title_full_unstemmed |
Efficacy of intravitreal Ranibizumab injection for choroidal neovascularization secondary to pathologic myopia |
title_sort |
efficacy of intravitreal ranibizumab injection for choroidal neovascularization secondary to pathologic myopia |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
Guoji Yanke Zazhi |
issn |
1672-5123 1672-5123 |
publishDate |
2016-03-01 |
description |
AIM:To observe the efficacy and safety of intravitreal Ranibizumab injection in patiens with choroidal neovascularization(CNV)secondary to pathologic myopia.<p>METHODS:In this retrospective and comparative study,24 patients(25 eyes)with CNV secondary to pathologic myopia were enrolled. All patients were assessed by examinations of ETDRS visual acuity chart, preplaced-mirror ophthalmoscopy, fundus fluorescein angiography(FFA), indocyanine green angiography(ICGA)and optical coherence tomography(OCT). Patiens received intravitreally injected ranibizumab 0.5mg(0.05mL). Treatments were repeated if the follow-up indicated that it was necessary. The follow-up periods were 4~10mo. Best corrected visual acuity(BCVA), central macular thickness(CMT)and leakage of CNV before and after the treatment were compared. <p>RESULTS:No local or systemic complications occurred in any patients during the treatment or follow-up. The average time of injection was 1.52. The mean BCVA was 23.93±12.46 letters before the therapy. In the last follow-up, the mean BCVA was 40.63±7.25 letters, improved by 14.27±9.36 letters and the difference was statically significant(<i>t</i>=5.74, <i>P</i><0.05). The mean CMT was 363.47±119.62μm before treatments and 190.31±37.02μm after treatments which was 72.82±60.57 μm less than the pre-treatment values and the difference was statically significant(<i>t</i>=3.96, <i>P</i><0.05). <p>CONCLUSION:Intravitreal ranibizumab injection for CNV secondary to pathologic myopia is safe and effective, and this treatment can improve visual acuity, reduce retina edema and leakage of CNV. |
topic |
choroidal neovascularization drug therapy myopia degenerative antibodies monoclonal |
url |
http://ies.ijo.cn/cn_publish/2016/3/201603034.pdf |
work_keys_str_mv |
AT lihongcui efficacyofintravitrealranibizumabinjectionforchoroidalneovascularizationsecondarytopathologicmyopia AT zhiyang efficacyofintravitrealranibizumabinjectionforchoroidalneovascularizationsecondarytopathologicmyopia AT lixu efficacyofintravitrealranibizumabinjectionforchoroidalneovascularizationsecondarytopathologicmyopia |
_version_ |
1725655426103508992 |