Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.

Latently-infected CD4+ T cells are widely considered to be the major barrier to a cure for HIV. Much of our understanding of HIV latency comes from latency models and blood cells, but most HIV-infected cells reside in lymphoid tissues such as the gut. We hypothesized that tissue-specific environment...

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Bibliographic Details
Main Authors: Sushama Telwatte, Sulggi Lee, Ma Somsouk, Hiroyu Hatano, Christopher Baker, Philipp Kaiser, Peggy Kim, Tsui-Hua Chen, Jeffrey Milush, Peter W Hunt, Steven G Deeks, Joseph K Wong, Steven A Yukl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007357

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