Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds.

Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds.

The West Nile Virus (WNV) NS2B-NS3 protease is an attractive target for the development of therapeutics against this arboviral pathogen. In the present investigation, the screening of a small library of fifty-eight synthetic compounds against the NS2-NB3 protease of WNV is described. The following g...

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Bibliographic Details
Main Authors: André S de Oliveira, Poliana A R Gazolla, Ana Flávia C da S Oliveira, Wagner L Pereira, Lívia C de S Viol, Angélica F da S Maia, Edjon G Santos, Ítalo E P da Silva, Tiago A de Oliveira Mendes, Adalberto M da Silva, Roberto S Dias, Cynthia C da Silva, Marcelo D Polêto, Róbson R Teixeira, Sergio O de Paula
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0223017

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