New classification system of endometrial hyperplasia WHO 2014 and its clinical implications
Endometrial hyperplasia (EH) is a pathological condition characterised by hyperplastic changes in endometrial glandular and stromal structures lining the uterine cavity. Endometrial hyperplasia, particularly with atypia, is a significant clinical concern because it can be a precursor of endometrial...
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doaj-1a4d161b77b447f380151738875a7bd22020-11-25T02:29:56ZengTermedia Publishing HouseMenopause Review1643-88762299-00382017-10-0116310711110.5114/pm.2017.7058930784New classification system of endometrial hyperplasia WHO 2014 and its clinical implicationsKatarzyna SobczukAnna SobczukEndometrial hyperplasia (EH) is a pathological condition characterised by hyperplastic changes in endometrial glandular and stromal structures lining the uterine cavity. Endometrial hyperplasia, particularly with atypia, is a significant clinical concern because it can be a precursor of endometrial cancer. Accurate diagnosis of precancerous lesions of the endometrium and exclusion of coexisting endometrial carcinomas are absolutely required for the optimal management of patients. The classification of endometrial hyperplasia has had numerous terminology. According to the classification of WHO94, based on glandular complexity and nuclear atypia, EH is divided into four groups: non-atypical endometrial hyperplasia (simple, complex) and atypical endometrial hyperplasia (simple, complex). Estimated risk of progression of atypical hyperplasia to endometrial cancer is 8-29%. The American College of Obstetricians and Gynaecologists and the Society of Gynaecological Oncology states that endometrial intraepithelial neoplasia (EIN) classification is superior to the World Health Organisation (WHO 94) classification for histology of endometrial hyperplasia. However, the WHO classification system remains the most commonly used and reported in existing literature. The new classification, WHO 2014, accepted by the International Society of Gynaecological Pathologists, divided hyperplasia into two groups: benign hyperplasia and atypical hyperplasia/endometrial intraepithelial neoplasia (EIN). The WHO 2014 schema is more likely to successfully identify precancerous lesions than the WHO94 classification.https://www.termedia.pl/New-classification-system-of-endometrial-hyperplasia-WHO-2014-and-its-clinical-implications,4,30784,1,1.htmlWHO2014 EIN EWG classifications system endometrial intraepithelial neoplasia (EIN) endometrioid neoplasia (EN) endometrial hyperplasia benign endometrial hyperplasia atypical endometrial hyperplasia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katarzyna Sobczuk Anna Sobczuk |
spellingShingle |
Katarzyna Sobczuk Anna Sobczuk New classification system of endometrial hyperplasia WHO 2014 and its clinical implications Menopause Review WHO2014 EIN EWG classifications system endometrial intraepithelial neoplasia (EIN) endometrioid neoplasia (EN) endometrial hyperplasia benign endometrial hyperplasia atypical endometrial hyperplasia |
author_facet |
Katarzyna Sobczuk Anna Sobczuk |
author_sort |
Katarzyna Sobczuk |
title |
New classification system of endometrial hyperplasia WHO 2014 and its clinical implications |
title_short |
New classification system of endometrial hyperplasia WHO 2014 and its clinical implications |
title_full |
New classification system of endometrial hyperplasia WHO 2014 and its clinical implications |
title_fullStr |
New classification system of endometrial hyperplasia WHO 2014 and its clinical implications |
title_full_unstemmed |
New classification system of endometrial hyperplasia WHO 2014 and its clinical implications |
title_sort |
new classification system of endometrial hyperplasia who 2014 and its clinical implications |
publisher |
Termedia Publishing House |
series |
Menopause Review |
issn |
1643-8876 2299-0038 |
publishDate |
2017-10-01 |
description |
Endometrial hyperplasia (EH) is a pathological condition characterised by hyperplastic changes in endometrial glandular and stromal structures lining the uterine cavity. Endometrial hyperplasia, particularly with atypia, is a significant clinical concern because it can be a precursor of endometrial cancer. Accurate diagnosis of precancerous lesions of the endometrium and exclusion of coexisting endometrial carcinomas are absolutely required for the optimal management of patients. The classification of endometrial hyperplasia has had numerous terminology. According to the classification of WHO94, based on glandular complexity and nuclear atypia, EH is divided into four groups: non-atypical endometrial hyperplasia (simple, complex) and atypical endometrial hyperplasia (simple, complex). Estimated risk of progression of atypical hyperplasia to endometrial cancer is 8-29%. The American College of Obstetricians and Gynaecologists and the Society of Gynaecological Oncology states that endometrial intraepithelial neoplasia (EIN) classification is superior to the World Health Organisation (WHO 94) classification for histology of endometrial hyperplasia. However, the WHO classification system remains the most commonly used and reported in existing literature.
The new classification, WHO 2014, accepted by the International Society of Gynaecological Pathologists, divided hyperplasia into two groups: benign hyperplasia and atypical hyperplasia/endometrial intraepithelial neoplasia (EIN). The WHO 2014 schema is more likely to successfully identify precancerous lesions than the WHO94 classification. |
topic |
WHO2014 EIN EWG classifications system endometrial intraepithelial neoplasia (EIN) endometrioid neoplasia (EN) endometrial hyperplasia benign endometrial hyperplasia atypical endometrial hyperplasia |
url |
https://www.termedia.pl/New-classification-system-of-endometrial-hyperplasia-WHO-2014-and-its-clinical-implications,4,30784,1,1.html |
work_keys_str_mv |
AT katarzynasobczuk newclassificationsystemofendometrialhyperplasiawho2014anditsclinicalimplications AT annasobczuk newclassificationsystemofendometrialhyperplasiawho2014anditsclinicalimplications |
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