A natural variant of the essential host gene MMS21 restricts the parasitic 2-micron plasmid in Saccharomyces cerevisiae

A natural variant of the essential host gene MMS21 restricts the parasitic 2-micron plasmid in Saccharomyces cerevisiae

Antagonistic coevolution with selfish genetic elements (SGEs) can drive evolution of host resistance. Here, we investigated host suppression of 2-micron (2μ) plasmids, multicopy nuclear parasites that have co-evolved with budding yeasts. We developed SCAMPR (Single-Cell Assay for Measuring Plasmid R...

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Bibliographic Details
Main Authors: Michelle Hays, Janet M Young, Paula F Levan, Harmit S Malik
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
genetic conflicts
Smc5/6 complex
high-copy plasmids
QTL
natural isolates
Smc5/6
Online Access:https://elifesciences.org/articles/62337

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