Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer

Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer

Ovarian cancer is the most lethal gynecologic malignancy among women worldwide and is presumed to result from the presence of ovarian cancer stem cells. To overcome the limitation of current anticancer agents, another anticancer strategy is necessary to effectively target cancer stem cells in ovaria...

Full description

Bibliographic Details
Main Authors: Tae Hun Kim, Dong Hoon Suh, Mi-Kyung Kim, Yong Sang Song
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/132702
id doaj-1a69624e6fb04572bffc95e63cb31645
record_format Article
spelling doaj-1a69624e6fb04572bffc95e63cb316452020-11-24T21:24:35ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/132702132702Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian CancerTae Hun Kim0Dong Hoon Suh1Mi-Kyung Kim2Yong Sang Song3Department of Obstetrics and Gynecology, Korean Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 463-707, Republic of KoreaBiomedical Science Project, Brain Korea 21 Program for Leading Universities & Students, Seoul National University, Seoul 110-799, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110-799, Republic of KoreaOvarian cancer is the most lethal gynecologic malignancy among women worldwide and is presumed to result from the presence of ovarian cancer stem cells. To overcome the limitation of current anticancer agents, another anticancer strategy is necessary to effectively target cancer stem cells in ovarian cancer. In many types of malignancies, including ovarian cancer, metformin, one of the most popular antidiabetic drugs, has been demonstrated to exhibit chemopreventive and anticancer efficacy with respect to incidence and overall survival rates. Thus, the metabolic reprogramming of cancer and cancer stem cells driven by genetic alterations during carcinogenesis and cancer progression could be therapeutically targeted. In this review, the potential efficacy and anticancer mechanisms of metformin against ovarian cancer stem cells will be discussed.http://dx.doi.org/10.1155/2014/132702
collection DOAJ
language English
format Article
sources DOAJ
author Tae Hun Kim
Dong Hoon Suh
Mi-Kyung Kim
Yong Sang Song
spellingShingle Tae Hun Kim
Dong Hoon Suh
Mi-Kyung Kim
Yong Sang Song
Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
BioMed Research International
author_facet Tae Hun Kim
Dong Hoon Suh
Mi-Kyung Kim
Yong Sang Song
author_sort Tae Hun Kim
title Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
title_short Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
title_full Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
title_fullStr Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
title_full_unstemmed Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
title_sort metformin against cancer stem cells through the modulation of energy metabolism: special considerations on ovarian cancer
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description Ovarian cancer is the most lethal gynecologic malignancy among women worldwide and is presumed to result from the presence of ovarian cancer stem cells. To overcome the limitation of current anticancer agents, another anticancer strategy is necessary to effectively target cancer stem cells in ovarian cancer. In many types of malignancies, including ovarian cancer, metformin, one of the most popular antidiabetic drugs, has been demonstrated to exhibit chemopreventive and anticancer efficacy with respect to incidence and overall survival rates. Thus, the metabolic reprogramming of cancer and cancer stem cells driven by genetic alterations during carcinogenesis and cancer progression could be therapeutically targeted. In this review, the potential efficacy and anticancer mechanisms of metformin against ovarian cancer stem cells will be discussed.
url http://dx.doi.org/10.1155/2014/132702
work_keys_str_mv AT taehunkim metforminagainstcancerstemcellsthroughthemodulationofenergymetabolismspecialconsiderationsonovariancancer
AT donghoonsuh metforminagainstcancerstemcellsthroughthemodulationofenergymetabolismspecialconsiderationsonovariancancer
AT mikyungkim metforminagainstcancerstemcellsthroughthemodulationofenergymetabolismspecialconsiderationsonovariancancer
AT yongsangsong metforminagainstcancerstemcellsthroughthemodulationofenergymetabolismspecialconsiderationsonovariancancer
_version_ 1725987514082131968

Similar Items