Less Carcinogenic Chlorinated Estrogens Applicable to Hormone Replacement Therapy

Less Carcinogenic Chlorinated Estrogens Applicable to Hormone Replacement Therapy

Human estrogens prescribed for hormone replacement therapy (HRT) are known to be potent carcinogens. To find safer estrogens, several chlorinated estrogens were synthesized and their carcinogenic potential were determined. A pellet containing either 2-chloro-17β-estradiol (2-ClE<sub>2</sub&...

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Bibliographic Details
Main Authors: Yoshinori Okamoto, Hideto Jinno, Shinji Itoh, Shinya Shibutani
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
estrogen
chlorination
mammary tumor
uterotrophic activity
hormone replacement therapy
DNA damage
Online Access:https://www.mdpi.com/1422-0067/22/13/7222

Internet

https://www.mdpi.com/1422-0067/22/13/7222

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