Qatari Genotype May Contribute to Complications in Type 2 Diabetes
Objective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East popul...
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Online Access: | http://dx.doi.org/10.1155/2020/6356973 |
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doaj-1a82617f30234d129b29d7ae203184ef2020-11-25T03:08:46ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/63569736356973Qatari Genotype May Contribute to Complications in Type 2 DiabetesYoussra Dakroury0Stephen L. Atkin1Soha R. Dargham2Amal Robay3Juan Rodriguez-Flores4Ronald G. Crystal5Alexandra E. Butler6Weill Cornell Medicine-Qatar, PO Box 24144, Doha, QatarRoyal College of Surgeons in Ireland, BahrainWeill Cornell Medicine-Qatar, PO Box 24144, Doha, QatarWeill Cornell Medicine-Qatar, PO Box 24144, Doha, QatarDepartment of Genetic Medicine, Weill Cornell Medicine, New York, USADepartment of Genetic Medicine, Weill Cornell Medicine, New York, USADiabetes Research Center (DRC), Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha, QatarObjective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East population may be contributory. Therefore, three genotype-based Qatari ancestral groups, Q1 Arab Bedouin, Q2 Asian/Persian, and Q3 sub-Saharan African, with a fourth admixed group were correlated with T2DM prevalence and its complications to determine if they differed between the 4 Qatari ancestries, particularly for the SLMAP allele-associated diabetic retinopathy. Methods. In this cross-sectional study, 398 Qatari subjects, 220 with and 178 without T2DM, were genotyped by Affymetrix 500k SNP arrays. Ancestry was correlated with diabetes complications. Results. 398 subjects were included, the mean age was 49.8 years, and 56.8% were male. The genotype-based ancestry and T2DM prevalence were as follows: 164 (41.2%) with ancestry Q1, 60.4% with T2DM; 149 (37.4%) with ancestry Q2, 49.7% with T2DM; 31 (7.8%) with ancestry Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed” ancestry, 51.9% with T2DM. For patients with diabetes, hypertension (p<0.035) and retinopathy (p<0.016) were greater in the Q3 ancestry. Conclusion. These data suggest that the genotype may contribute to complication risk, as exemplified by the increase in hypertension and retinopathy in the Q3 ancestry, though the SLMAP allele was not implicated; however, diabetes prevalence did not differ between the four Qatari ancestries.http://dx.doi.org/10.1155/2020/6356973 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Youssra Dakroury Stephen L. Atkin Soha R. Dargham Amal Robay Juan Rodriguez-Flores Ronald G. Crystal Alexandra E. Butler |
spellingShingle |
Youssra Dakroury Stephen L. Atkin Soha R. Dargham Amal Robay Juan Rodriguez-Flores Ronald G. Crystal Alexandra E. Butler Qatari Genotype May Contribute to Complications in Type 2 Diabetes Journal of Diabetes Research |
author_facet |
Youssra Dakroury Stephen L. Atkin Soha R. Dargham Amal Robay Juan Rodriguez-Flores Ronald G. Crystal Alexandra E. Butler |
author_sort |
Youssra Dakroury |
title |
Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
title_short |
Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
title_full |
Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
title_fullStr |
Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
title_full_unstemmed |
Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
title_sort |
qatari genotype may contribute to complications in type 2 diabetes |
publisher |
Hindawi Limited |
series |
Journal of Diabetes Research |
issn |
2314-6745 2314-6753 |
publishDate |
2020-01-01 |
description |
Objective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East population may be contributory. Therefore, three genotype-based Qatari ancestral groups, Q1 Arab Bedouin, Q2 Asian/Persian, and Q3 sub-Saharan African, with a fourth admixed group were correlated with T2DM prevalence and its complications to determine if they differed between the 4 Qatari ancestries, particularly for the SLMAP allele-associated diabetic retinopathy. Methods. In this cross-sectional study, 398 Qatari subjects, 220 with and 178 without T2DM, were genotyped by Affymetrix 500k SNP arrays. Ancestry was correlated with diabetes complications. Results. 398 subjects were included, the mean age was 49.8 years, and 56.8% were male. The genotype-based ancestry and T2DM prevalence were as follows: 164 (41.2%) with ancestry Q1, 60.4% with T2DM; 149 (37.4%) with ancestry Q2, 49.7% with T2DM; 31 (7.8%) with ancestry Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed” ancestry, 51.9% with T2DM. For patients with diabetes, hypertension (p<0.035) and retinopathy (p<0.016) were greater in the Q3 ancestry. Conclusion. These data suggest that the genotype may contribute to complication risk, as exemplified by the increase in hypertension and retinopathy in the Q3 ancestry, though the SLMAP allele was not implicated; however, diabetes prevalence did not differ between the four Qatari ancestries. |
url |
http://dx.doi.org/10.1155/2020/6356973 |
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