Endothelin-1 Level in Patients with Simple Renal Cyst
Introduction: Endothelin-1 (ET-1) is potent vasoconstrictive peptide and elevated ET-1 levels are associated with hypertension, endothelial dysfunction and atherosclerosis. Research on (ET-1) has demonstrated that elevated ET-1 levels in autosomal dominant polycystic kidney disease leads to systemic...
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doaj-1a975d119840464e83517f8a4bb7deb52020-11-25T01:26:08ZengPensoft PublishersFolia Medica 0204-80431314-21432019-12-0161454555010.3897/folmed.61.e4795447954Endothelin-1 Level in Patients with Simple Renal CystSelahattin Çalişkan0Mustafa Sungur1Bariş Eser2Mustafa Kanbay3Hüseyin Kocan4Ramazan Topaktas5Istanbul Reyap HospitalHitit University, Çorum Erol Olçok Training and Research HospitalHitit University, Çorum Erol Olçok Training and Research HospitalKanuni Sultan Süleyman Training and Research HospitalKanuni Sultan Süleyman Training and Research HospitalHaydarpasa Numune Training and Research HospitalIntroduction: Endothelin-1 (ET-1) is potent vasoconstrictive peptide and elevated ET-1 levels are associated with hypertension, endothelial dysfunction and atherosclerosis. Research on (ET-1) has demonstrated that elevated ET-1 levels in autosomal dominant polycystic kidney disease leads to systemic hypertension. The prevalence of simple renal cysts increases with age and the association with simple renal cyst and hypertension is not clear. The aim of this study was to investigate the ET-1 levels in patients with simple renal cyst and compare them with those in healthy adults.Materials and methods: The study included patients that underwent laparoscopic renal cyst decortication in the Department of Urology and healthy controls. Serum and urinary ET-1 levels were measured before surgery and one month after it in the patients with simple renal cyst. Serum ET-1 levels were measured in healthy adult patients. Ambulatory blood pressure was measured in all patients. Glomerular filtration rate was measured according to the chronic kidney disease epidemiology collaboration formula.Results: Thirty-two patients were included in the present study. Of these, 16 patients with simple renal cyst were allocated into group 1 and 16 healthy patients - in group 2. There was no significant difference between systolic and diastolic blood pressure between the groups (p=0.820 and p=0.618, respectively). Serum EL-1 levels were significantly lower in group 1 than those in group 2 (p=0.036). Interestingly, serum EL-1 levels were increased after laparoscopic cyst decortication and there was no significant difference with healthy patients (p=0.429).Conclusions: The present study demonstrated that serum EL-1 level in patients with simple renal cyst was lower than that in healthy people. Further studies are needed to investigate the EL-1 levels in simple renal cyst patients.https://foliamedica.bg/article/47954/download/pdf/Bosniakdecorticationendothelin-1simple renal |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Selahattin Çalişkan Mustafa Sungur Bariş Eser Mustafa Kanbay Hüseyin Kocan Ramazan Topaktas |
spellingShingle |
Selahattin Çalişkan Mustafa Sungur Bariş Eser Mustafa Kanbay Hüseyin Kocan Ramazan Topaktas Endothelin-1 Level in Patients with Simple Renal Cyst Folia Medica Bosniak decortication endothelin-1 simple renal |
author_facet |
Selahattin Çalişkan Mustafa Sungur Bariş Eser Mustafa Kanbay Hüseyin Kocan Ramazan Topaktas |
author_sort |
Selahattin Çalişkan |
title |
Endothelin-1 Level in Patients with Simple Renal Cyst |
title_short |
Endothelin-1 Level in Patients with Simple Renal Cyst |
title_full |
Endothelin-1 Level in Patients with Simple Renal Cyst |
title_fullStr |
Endothelin-1 Level in Patients with Simple Renal Cyst |
title_full_unstemmed |
Endothelin-1 Level in Patients with Simple Renal Cyst |
title_sort |
endothelin-1 level in patients with simple renal cyst |
publisher |
Pensoft Publishers |
series |
Folia Medica |
issn |
0204-8043 1314-2143 |
publishDate |
2019-12-01 |
description |
Introduction: Endothelin-1 (ET-1) is potent vasoconstrictive peptide and elevated ET-1 levels are associated with hypertension, endothelial dysfunction and atherosclerosis. Research on (ET-1) has demonstrated that elevated ET-1 levels in autosomal dominant polycystic kidney disease leads to systemic hypertension. The prevalence of simple renal cysts increases with age and the association with simple renal cyst and hypertension is not clear. The aim of this study was to investigate the ET-1 levels in patients with simple renal cyst and compare them with those in healthy adults.Materials and methods: The study included patients that underwent laparoscopic renal cyst decortication in the Department of Urology and healthy controls. Serum and urinary ET-1 levels were measured before surgery and one month after it in the patients with simple renal cyst. Serum ET-1 levels were measured in healthy adult patients. Ambulatory blood pressure was measured in all patients. Glomerular filtration rate was measured according to the chronic kidney disease epidemiology collaboration formula.Results: Thirty-two patients were included in the present study. Of these, 16 patients with simple renal cyst were allocated into group 1 and 16 healthy patients - in group 2. There was no significant difference between systolic and diastolic blood pressure between the groups (p=0.820 and p=0.618, respectively). Serum EL-1 levels were significantly lower in group 1 than those in group 2 (p=0.036). Interestingly, serum EL-1 levels were increased after laparoscopic cyst decortication and there was no significant difference with healthy patients (p=0.429).Conclusions: The present study demonstrated that serum EL-1 level in patients with simple renal cyst was lower than that in healthy people. Further studies are needed to investigate the EL-1 levels in simple renal cyst patients. |
topic |
Bosniak decortication endothelin-1 simple renal |
url |
https://foliamedica.bg/article/47954/download/pdf/ |
work_keys_str_mv |
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