Circular RNA hsa_circ_009755 downregulation correlates with clinicopathology in oral squamous cell carcinoma

• Main Authors: Wang Z, Tang J, Wang Y, Sun S, Chen Y, Shen Y, Yang HY
• Format: Article
• Language: English
• Published: Dove Medical Press 2019-05-01
• Series: OncoTargets and Therapy
• Subjects: oral squamous cell carcinoma; circular RNA; biomarker; hsa_circ_009755
• Online Access: https://www.dovepress.com/circular-rna-hsacirc009755-downregulation-correlates-with-clinicopatho-peer-reviewed-article-OTT

Zihong Wang,1,2* Jing Tang,3* Yufan Wang,1 Shuai Sun,1 Yuling Chen,1 Yuehong Shen,1 Hong-Yu Yang11Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of China; 2Peking University Shenzhen Hospital Clinical College, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 3Jingzhou Central Hospital, Jingzhou, Hubei, People’s Republic of China *These authors contributed equally to this work  Background: Oral squamous cell carcinoma (OSCC) is the most frequent oral malignancy in humans. Increasing numbers of studies suggest that circular RNAs (circRNAs) play a major role in tumorigenesis and tumor progression.Purpose: We aimed to identify differently expressed circRNA in OSCC and adjacent normal tissue. As well as to study the correlation of circRNA expression with clinicopathological feature in patients with OSCC.Patients and methods: Primary OSCC tissues and adjacent normal tissues from twenty-seven OSCC patients were collected. The expression level of hsa_circ_009755 were analyzed by qRT-PCR.Results: The measurement results from qRT-PCR revealed that hsa_circ_009755 expression was low in OSCC tissue samples and cell lines, and the low expression of hsa_circ_009755 was closely related to a clinicopathological feature in patients with OSCC. Moreover, the area under the receiver operating characteristic curve was 0.782, which indicates the sensitivity and specificity of the diagnostic value.Conclusion: Our data indicates that hsa_circ_009755 could serve as a potential biomarker for OSCC diagnosis.Keywords: oral squamous cell carcinoma, circular RNA, biomarker, hsa_circ_009755