Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function

Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function

A better understanding of the molecular links between obesity and disease is potentially of great benefit for society. In this paper we discuss proposed mechanisms whereby bariatric surgery improves metabolic health, including acute effects on glucose metabolism and long-term effects on metabolic ti...

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Main Authors: Simon N. Dankel, Vidar Staalesen, Bodil Bjørndal, Rolf K. Berge, Gunnar Mellgren, Lena Burri
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Obesity
Online Access:http://dx.doi.org/10.1155/2011/435245
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spelling doaj-1aad43571be24f188d09da75be06aa982020-11-24T22:37:14ZengHindawi LimitedJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/435245435245Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial FunctionSimon N. Dankel0Vidar Staalesen1Bodil Bjørndal2Rolf K. Berge3Gunnar Mellgren4Lena Burri5Institute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayA better understanding of the molecular links between obesity and disease is potentially of great benefit for society. In this paper we discuss proposed mechanisms whereby bariatric surgery improves metabolic health, including acute effects on glucose metabolism and long-term effects on metabolic tissues (adipose tissue, skeletal muscle, and liver) and mitochondrial function. More short-term randomized controlled trials should be performed that include simultaneous measurement of metabolic parameters in different tissues, such as tissue gene expression, protein profile, and lipid content. By directly comparing different surgical procedures using a wider array of metabolic parameters, one may further unravel the mechanisms of aberrant metabolic regulation in obesity and related disorders.http://dx.doi.org/10.1155/2011/435245
collection DOAJ
language English
format Article
sources DOAJ
author Simon N. Dankel
Vidar Staalesen
Bodil Bjørndal
Rolf K. Berge
Gunnar Mellgren
Lena Burri
spellingShingle Simon N. Dankel
Vidar Staalesen
Bodil Bjørndal
Rolf K. Berge
Gunnar Mellgren
Lena Burri
Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function
Journal of Obesity
author_facet Simon N. Dankel
Vidar Staalesen
Bodil Bjørndal
Rolf K. Berge
Gunnar Mellgren
Lena Burri
author_sort Simon N. Dankel
title Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function
title_short Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function
title_full Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function
title_fullStr Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function
title_full_unstemmed Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function
title_sort tissue-specific effects of bariatric surgery including mitochondrial function
publisher Hindawi Limited
series Journal of Obesity
issn 2090-0708
2090-0716
publishDate 2011-01-01
description A better understanding of the molecular links between obesity and disease is potentially of great benefit for society. In this paper we discuss proposed mechanisms whereby bariatric surgery improves metabolic health, including acute effects on glucose metabolism and long-term effects on metabolic tissues (adipose tissue, skeletal muscle, and liver) and mitochondrial function. More short-term randomized controlled trials should be performed that include simultaneous measurement of metabolic parameters in different tissues, such as tissue gene expression, protein profile, and lipid content. By directly comparing different surgical procedures using a wider array of metabolic parameters, one may further unravel the mechanisms of aberrant metabolic regulation in obesity and related disorders.
url http://dx.doi.org/10.1155/2011/435245
work_keys_str_mv AT simonndankel tissuespecificeffectsofbariatricsurgeryincludingmitochondrialfunction
AT vidarstaalesen tissuespecificeffectsofbariatricsurgeryincludingmitochondrialfunction
AT bodilbjørndal tissuespecificeffectsofbariatricsurgeryincludingmitochondrialfunction
AT rolfkberge tissuespecificeffectsofbariatricsurgeryincludingmitochondrialfunction
AT gunnarmellgren tissuespecificeffectsofbariatricsurgeryincludingmitochondrialfunction
AT lenaburri tissuespecificeffectsofbariatricsurgeryincludingmitochondrialfunction
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