High levels of anti-Leishmania IgG3 and low CD4+ T cells count were associated with relapses in visceral leishmaniasis

High levels of anti-Leishmania IgG3 and low CD4+ T cells count were associated with relapses in visceral leishmaniasis

Abstract Background Visceral leishmaniasis (VL) is severe and potentially fatal. Brazil is one of the countries with the greatest endemicity for the disease in the world. The reduction of CD4+ T lymphocytes, B cells activation and high levels of inflammatory cytokines (IL-6/IL-8/TNF/IL-1β), plasma L...

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Bibliographic Details
Main Authors: Renata Caetano Kuschnir, Leonardo Soares Pereira, Maria Rita Teixeira Dutra, Ludmila de Paula, Maria Luciana Silva-Freitas, Gabriela Corrêa-Castro, Simone da Costa Cruz Silva, Glaucia Cota, Joanna Reis Santos-Oliveira, Alda Maria Da-Cruz
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Infectious Diseases
Subjects:
Visceral leishmaniasis
Relapses
Clinical follow-up
Immune response
Online Access:https://doi.org/10.1186/s12879-021-06051-5

Internet

https://doi.org/10.1186/s12879-021-06051-5

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