Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion

Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion

Novel therapeutic strategies are needed for the treatment of rhabdomyosarcoma (RMS), the most common soft-tissue sarcoma in children. By using a combination of cell surface proteomics and transcriptomic profiling of RMS and normal muscle, we generated a catalog of targetable cell surface proteins en...

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Bibliographic Details
Main Authors: Roxane R. Lavoie, Patricio C. Gargollo, Mohamed E. Ahmed, Yohan Kim, Emily Baer, Doris A. Phelps, Cristine M. Charlesworth, Benjamin J. Madden, Liguo Wang, Peter J. Houghton, John Cheville, Haidong Dong, Candace F. Granberg, Fabrice Lucien
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
rhabdomyosarcoma
targeted therapies
cell surface proteomics
B7-H3
Online Access:https://www.mdpi.com/2072-6694/13/18/4528

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