Overexpression of mitochondrial GPAT in rat hepatocytes leads to decreased fatty acid oxidation and increased glycerolipid biosynthesis
Glycerol-3-phosphate acyltransferase (GPAT) catalyses the first committed step in glycerolipid biosynthesis. The mitochondrial isoform (mtGPAT) is mainly expressed in liver, where it is highly regulated, indicating that mtGPAT may have a unique role in hepatic fatty acid metabolism. Because both mtG...
Main Authors: | Daniel Lindén, Lena William-Olsson, Magdalena Rhedin, Anna-Karin Asztély, John C. Clapham, Sandra Schreyer |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2004-07-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520317843 |
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