Genomic Analysis Identifies Mutations Concerning Drug-Resistance and Beijing Genotype in Multidrug-Resistant Mycobacterium tuberculosis Isolated From China

Genomic Analysis Identifies Mutations Concerning Drug-Resistance and Beijing Genotype in Multidrug-Resistant Mycobacterium tuberculosis Isolated From China

Development of modern genomics provides us an effective method to understand the molecular mechanism of drug resistance and diagnose drug-resistant Mycobacterium tuberculosis. In this study, mutations in 18 genes or intergenic regions acquired by whole-genome sequencing (WGS) of 183 clinical M. tube...

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Bibliographic Details
Main Authors: Li Wan, Haican Liu, Machao Li, Yi Jiang, Xiuqin Zhao, Zhiguang Liu, Kanglin Wan, Guilian Li, Cha-xiang Guan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
resistance
whole-genome sequencing
mutation
Beijing genotype
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01444/full

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