Epidemiology of sepsis in cancer patients in Victoria, Australia: a population‐based study using linked data
Abstract Objective: To determine the clinical characteristics, outcomes and longitudinal trends of sepsis occurring in cancer patients. Method: Retrospective study using statewide Victorian Cancer Registry data linked to various administrative datasets. Results: Among 215,763 incident cancer patient...
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Online Access: | https://doi.org/10.1111/1753-6405.12935 |
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doaj-1acacb15a5204c79a28b28566cdca0b22020-11-25T01:30:12ZengWileyAustralian and New Zealand Journal of Public Health1326-02001753-64052020-02-01441535810.1111/1753-6405.12935Epidemiology of sepsis in cancer patients in Victoria, Australia: a population‐based study using linked dataLuc te Marvelde0Ann Whitfield1Jennie Shepheard2Carla Read3Roger L. Milne4Kathryn Whitfield5Cancer Epidemiology Division Cancer Council VictoriaRetiredInformation Management and Standards Victorian Agency for Health Information VictoriaInformation Management and Standards Victorian Agency for Health Information VictoriaCancer Epidemiology Division Cancer Council VictoriaCancer Strategy & Development, Department of Health and Human Services VictoriaAbstract Objective: To determine the clinical characteristics, outcomes and longitudinal trends of sepsis occurring in cancer patients. Method: Retrospective study using statewide Victorian Cancer Registry data linked to various administrative datasets. Results: Among 215,763 incident cancer patients, incidence of sepsis within one year of cancer diagnosis was estimated at 6.4%. The incidence of sepsis was higher in men, younger patients, patients diagnosed with haematological malignancies and those with de novo metastatic disease. Of the 13,316 patients with a first admission with sepsis, 55% had one or more organ failures, 29% required care within an intensive care unit and 13% required mechanical ventilation. Treatments associated with the highest sepsis incidence were stem cell/bone marrow transplant (33%), major surgery (4.4%), chemotherapy (1.1%) and radical radiotherapy (0.6%). The incidence of sepsis with organ failure increased between 2008 and 2015, while 90‐day mortality decreased. Conclusions: Sepsis in patients with cancer has high mortality and occurs most frequently in the first year after cancer diagnosis. Implications for public health: The number of cancer patients diagnosed with sepsis is expected to increase, causing a substantial burden on patients and the healthcare system.https://doi.org/10.1111/1753-6405.12935cancersepsisepidemiology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luc te Marvelde Ann Whitfield Jennie Shepheard Carla Read Roger L. Milne Kathryn Whitfield |
spellingShingle |
Luc te Marvelde Ann Whitfield Jennie Shepheard Carla Read Roger L. Milne Kathryn Whitfield Epidemiology of sepsis in cancer patients in Victoria, Australia: a population‐based study using linked data Australian and New Zealand Journal of Public Health cancer sepsis epidemiology |
author_facet |
Luc te Marvelde Ann Whitfield Jennie Shepheard Carla Read Roger L. Milne Kathryn Whitfield |
author_sort |
Luc te Marvelde |
title |
Epidemiology of sepsis in cancer patients in Victoria, Australia: a population‐based study using linked data |
title_short |
Epidemiology of sepsis in cancer patients in Victoria, Australia: a population‐based study using linked data |
title_full |
Epidemiology of sepsis in cancer patients in Victoria, Australia: a population‐based study using linked data |
title_fullStr |
Epidemiology of sepsis in cancer patients in Victoria, Australia: a population‐based study using linked data |
title_full_unstemmed |
Epidemiology of sepsis in cancer patients in Victoria, Australia: a population‐based study using linked data |
title_sort |
epidemiology of sepsis in cancer patients in victoria, australia: a population‐based study using linked data |
publisher |
Wiley |
series |
Australian and New Zealand Journal of Public Health |
issn |
1326-0200 1753-6405 |
publishDate |
2020-02-01 |
description |
Abstract Objective: To determine the clinical characteristics, outcomes and longitudinal trends of sepsis occurring in cancer patients. Method: Retrospective study using statewide Victorian Cancer Registry data linked to various administrative datasets. Results: Among 215,763 incident cancer patients, incidence of sepsis within one year of cancer diagnosis was estimated at 6.4%. The incidence of sepsis was higher in men, younger patients, patients diagnosed with haematological malignancies and those with de novo metastatic disease. Of the 13,316 patients with a first admission with sepsis, 55% had one or more organ failures, 29% required care within an intensive care unit and 13% required mechanical ventilation. Treatments associated with the highest sepsis incidence were stem cell/bone marrow transplant (33%), major surgery (4.4%), chemotherapy (1.1%) and radical radiotherapy (0.6%). The incidence of sepsis with organ failure increased between 2008 and 2015, while 90‐day mortality decreased. Conclusions: Sepsis in patients with cancer has high mortality and occurs most frequently in the first year after cancer diagnosis. Implications for public health: The number of cancer patients diagnosed with sepsis is expected to increase, causing a substantial burden on patients and the healthcare system. |
topic |
cancer sepsis epidemiology |
url |
https://doi.org/10.1111/1753-6405.12935 |
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AT luctemarvelde epidemiologyofsepsisincancerpatientsinvictoriaaustraliaapopulationbasedstudyusinglinkeddata AT annwhitfield epidemiologyofsepsisincancerpatientsinvictoriaaustraliaapopulationbasedstudyusinglinkeddata AT jennieshepheard epidemiologyofsepsisincancerpatientsinvictoriaaustraliaapopulationbasedstudyusinglinkeddata AT carlaread epidemiologyofsepsisincancerpatientsinvictoriaaustraliaapopulationbasedstudyusinglinkeddata AT rogerlmilne epidemiologyofsepsisincancerpatientsinvictoriaaustraliaapopulationbasedstudyusinglinkeddata AT kathrynwhitfield epidemiologyofsepsisincancerpatientsinvictoriaaustraliaapopulationbasedstudyusinglinkeddata |
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