Targeting CCN Proteins in Rheumatoid Arthritis and Osteoarthritis

Targeting CCN Proteins in Rheumatoid Arthritis and Osteoarthritis

The CCN family of matricellular proteins (CYR61/CCN1, CTGF/CCN2, NOV/CCN3 and WISP1-2-3/CCN4-5-6) are essential players in the key pathophysiological processes of angiogenesis, wound healing and inflammation. These proteins are well recognized for their important roles in many cellular processes, in...

Full description

Bibliographic Details
Main Authors:	Iona J. MacDonald, Chien-Chung Huang, Shan-Chi Liu, Yen-You Lin, Chih-Hsin Tang
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	International Journal of Molecular Sciences
Subjects:	CCN proteins CCN family rheumatoid arthritis osteoarthritis juvenile idiopathic arthritis
Online Access:	https://www.mdpi.com/1422-0067/22/9/4340

Similar Items

Atrial expression of the CCN1 and CCN2 proteins in chronic heart failure
by: Lech Chyczewski, et al.
Published: (2012-04-01)

Biologic therapy of rheumatoid arthritis
by: Damjanov Nemanja, et al.
Published: (2009-01-01)

Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of Ccn2
by: Craig M. Keenan, et al.
Published: (2020-07-01)

CCN-Based Therapeutic Peptides Modify Pancreatic Ductal Adenocarcinoma Microenvironment and Decrease Tumor Growth in Combination with Chemotherapy
by: Andrea Resovi, et al.
Published: (2020-04-01)

Role of Matricellular CCN Proteins in Skeletal Muscle: Focus on CCN2/CTGF and Its Regulation by Vasoactive Peptides
by: Daniela L. Rebolledo, et al.
Published: (2021-05-01)

Clinical and CT Scan Evaluation of Temporomandibular Joints with Osteoarthritis and Rheumatoid Arthritis
by: Abhijeet Deoghare, et al.
Published: (2010-01-01)

CCN2/CTGF silencing blocks cell aggregation in embryonal carcinoma P19 cell
by: D.P. Aguiar, et al.
Published: (2011-03-01)

CCN2/CTGF silencing blocks cell aggregation in embryonal carcinoma P19 cell
by: D.P. Aguiar, et al.
Published: (2011-03-01)

Reconsidering the Role of Melatonin in Rheumatoid Arthritis
by: Iona J. MacDonald, et al.
Published: (2020-04-01)

ABATACEPT IN TREATMENT OF JUVENILE IDIOPATHIC ARTHRITIS: INTERNATIONAL DATA AND EXPERIENCE OF USAGE IN THE REPUBLIC OF MORDOVIA
by: L. A. Balykova, et al.
Published: (2014-03-01)

Pachydermodactyly-symmetric soft tissue swelling around proximal interphalangeal joints may be misdiagnosed for arthritis
by: Evangelia Georgiou, et al.
Published: (2016-01-01)

Clinical profile of juvenile idiopathic arthritis from a tertiary care hospital in Northern India
by: Arun Hegde, et al.
Published: (2020-01-01)

Prevalence and severity of periodontitis in patients with established rheumatoid arthritis and osteoarthritis
by: Pooja R Disale, et al.
Published: (2020-01-01)

Hepatic Wnt1 Inducible Signaling Pathway Protein 1 (WISP-1/CCN4) Associates with Markers of Liver Fibrosis in Severe Obesity
by: Olga Pivovarova-Ramich, et al.
Published: (2021-04-01)

Zinc and Cadmium in the Aetiology and Pathogenesis of Osteoarthritis and Rheumatoid Arthritis
by: Theoharris Frangos, et al.
Published: (2021-12-01)

Analysis of juvenile idiopathic arthritis associated uveitis in India over the last 16 years
by: Sudharshan S, et al.
Published: (2007-01-01)

A fresh look at angiogenesis in juvenile idiopathic arthritis
by: Joanna Świdrowska-Jaros, et al.
Published: (2018-10-01)

Management of temporomandibular joint arthritis in adult rheumatology practices: a survey of adult rheumatologists
by: Ringold Sarah, et al.
Published: (2012-08-01)

Cytokine data obtained from synovial stromal cells of patients with rheumatoid arthritis or osteoarthritis
by: Johanna A. Huhtakangas, et al.
Published: (2017-06-01)

Study of interleukin 33 in rheumatoid arthritis versus osteoarthritis patients
by: Aliaa M. Abd El-Aziz Farag, et al.
Published: (2017-01-01)

CCN6 mutation detection in Chinese patients with progressive pseudo‐rheumatoid dysplasia and identification of four novel mutations
by: Yingjie Wang, et al.
Published: (2020-07-01)

Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: A ten-year retrospective study
by: Hu-Yuan Tsai, et al.
Published: (2012-10-01)

Developing models of aerosol representation to investigate composition, evolution, optical properties, and CCN spectra using measurements of size-resolved hygroscopicity
by: Gasparini, Roberto
Published: (2006)

Systemic-onset juvenile idiopathic arthritis in a child with thalassemia major
by: Pitta Mary Dayana, et al.
Published: (2018-01-01)

Use of Herbal Medications for Treatment of Osteoarthritis and Rheumatoid Arthritis
by: Breanna N. Lindler, et al.
Published: (2020-10-01)

Comparative Analysis of Fecal Microbiota Composition Between Rheumatoid Arthritis and Osteoarthritis Patients
by: Jin-Young Lee, et al.
Published: (2019-09-01)

Influence of Common Assumptions Regarding Aerosol Composition and Mixing State on Predicted CCN Concentration
by: Manasi Mahish, et al.
Published: (2018-02-01)

Are we overlooking osteoarthritis? – A comparative study of pain, function and quality of life in patiens with hand osteoarthritis and rheumatoid arthritis
by: Diogo Esperança Almeida, et al.
Published: (2020-07-01)

Ultrasound findings in knee osteoarthritis and rheumatoid arthritis compared to MRI
by: Hamidreza Sadeghian, et al.
Published: (2018-08-01)

Heterogeneous CCN Cache Allocation Strategy With Collaboration Support
by: Jianhui Lv, et al.
Published: (2021-01-01)

Correlation of osteoarthritis or rheumatoid arthritis with bone mineral density in adults aged 20–59 years
by: Zhongxin Zhu, et al.
Published: (2021-03-01)

Implications of Angiogenesis Involvement in Arthritis
by: Iona J. MacDonald, et al.
Published: (2018-07-01)

Modern concepts of vitamin D role in juvenile idiopathic arthritis in children (review)
by: Y.V. Khadzhynova
Published: (2019-08-01)

Research of Pathogenesis and Novel Therapeutics in Arthritis
by: Chih-Hsin Tang
Published: (2019-04-01)

Juvenile idiopathic arthritis morbidity rate in rural and urban areas of Poland 2008–2012
by: Małgorzata Tłustochowicz, et al.
Published: (2015-12-01)

Tenascin-C in Osteoarthritis and Rheumatoid Arthritis
by: Masahiro Hasegawa, et al.
Published: (2020-09-01)

Epidemiologic investigation of juvenile rheumatoid arthritis: a ten-year study
by: Abdolreza Malek, et al.
Published: (2014-06-01)

Regulation of osteoblast differentiation mediated by BMP, Notch, and CCN3/NOV
by: Akira Yamaguchi, et al.
Published: (2008-07-01)

Exercise therapy for juvenile idiopathic arthritis
by: Kern, Madelyn
Published: (2019)

GOLIMUMAB — A NEW TNF α-BLOCKER. THE REVIEW OF THE EFFICACY AND SAFETY EVALUATION RESULTS
by: R. V. Denisova, et al.
Published: (2012-07-01)