Dietary Chicory Inulin-Rich Meal Exerts Greater Healing Effects than Fructooligosaccharide Preparation in Rats with Trinitrobenzenesulfonic Acid-Induced Necrotic Colitis
The aim of the study was to compare the effects of chicory root inulin-rich meal (containing polyphenolic fraction as well) and pure fructooligosaccharides (FOS) on necrotic colitis induced with trinitrobenzenesulfonic acid (TNBS) in Wistar rats. Both chicory preparations significantly reduced the p...
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doaj-1ad0bf26908646cea19ede0327bda9e62020-11-25T03:04:44ZengInstitute of Animal Reproduction and Food ResearchPolish Journal of Food and Nutrition Sciences2083-60072019-03-0169214715510.31883/pjfns-2019-0013104611Dietary Chicory Inulin-Rich Meal Exerts Greater Healing Effects than Fructooligosaccharide Preparation in Rats with Trinitrobenzenesulfonic Acid-Induced Necrotic ColitisBartosz Fotschki0Adam Jurgoński1Joanna Fotschki2Michał Majewski3Katarzyna Ognik4Jerzy Juśkiewicz5BIOLOGICAL FUNCTION OF FOOD, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, PolandBIOLOGICAL FUNCTION OF FOOD, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, PolandIMMUNOLOGY AND FOOD MICROBIOLOGY, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, PolandPHARMACOLOGY AND TOXICOLOGY, University of Warmia and Mazury, Faculty of Medicine, PolandBIOCHEMISTRY AND TOXICOLOGY, Animal Sciences and Bioeconomy, University of Life Sciences, Faculty of Biology, PolandBIOLOGICAL FUNCTION OF FOOD, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, PolandThe aim of the study was to compare the effects of chicory root inulin-rich meal (containing polyphenolic fraction as well) and pure fructooligosaccharides (FOS) on necrotic colitis induced with trinitrobenzenesulfonic acid (TNBS) in Wistar rats. Both chicory preparations significantly reduced the pH of colonic digesta and favourably lowered the caecal activity of bacterial β-glucuronidase as well as the caecal concentration of putrefactive short-chain fatty acids in comparison to the control TNBS rats. Both chicory preparations enhanced the production of total short-chain fatty acid (SCFA pool) and concentration of anti-inflammatory propionic acid in the caecal digesta. Nevertheless, only dietary chicory meal favourably increased the total SCFA concentration and thus decreased the pH of caecal digesta. Increased caecal SCFA production may explain observed greater reduction in mucosal necrosis and increase in glandular mucosal regeneration in rats fed a diet with chicory root meal. Both chicory preparations beneficially regulated physiological parameters in the lower part of the rat intestinal tract after TNBS-induced colitis, however the dietary treatment with chicory meal showed stronger reduction of mucosal disturbances caused by colitis. Those beneficial effects might be related to higher polymerization of inulin vs. FOS and presence of biologically active compounds in the meal, i.e., phenolic compounds, which have strong impact on intestinal microbial activity and thus indirectly alleviated mucosal disturbances caused by colitis.http://www.journalssystem.com/pjfns/Dietary-chicory-inulin-rich-meal-exerts-greater-healing-effects-than-fructooligosaccharide,104611,0,2.htmltnbs-induced colitismicrobiota activityshort-chain fatty acidschicory rootswistar rat |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bartosz Fotschki Adam Jurgoński Joanna Fotschki Michał Majewski Katarzyna Ognik Jerzy Juśkiewicz |
spellingShingle |
Bartosz Fotschki Adam Jurgoński Joanna Fotschki Michał Majewski Katarzyna Ognik Jerzy Juśkiewicz Dietary Chicory Inulin-Rich Meal Exerts Greater Healing Effects than Fructooligosaccharide Preparation in Rats with Trinitrobenzenesulfonic Acid-Induced Necrotic Colitis Polish Journal of Food and Nutrition Sciences tnbs-induced colitis microbiota activity short-chain fatty acids chicory roots wistar rat |
author_facet |
Bartosz Fotschki Adam Jurgoński Joanna Fotschki Michał Majewski Katarzyna Ognik Jerzy Juśkiewicz |
author_sort |
Bartosz Fotschki |
title |
Dietary Chicory Inulin-Rich Meal Exerts Greater Healing Effects than Fructooligosaccharide Preparation in Rats with Trinitrobenzenesulfonic Acid-Induced Necrotic Colitis |
title_short |
Dietary Chicory Inulin-Rich Meal Exerts Greater Healing Effects than Fructooligosaccharide Preparation in Rats with Trinitrobenzenesulfonic Acid-Induced Necrotic Colitis |
title_full |
Dietary Chicory Inulin-Rich Meal Exerts Greater Healing Effects than Fructooligosaccharide Preparation in Rats with Trinitrobenzenesulfonic Acid-Induced Necrotic Colitis |
title_fullStr |
Dietary Chicory Inulin-Rich Meal Exerts Greater Healing Effects than Fructooligosaccharide Preparation in Rats with Trinitrobenzenesulfonic Acid-Induced Necrotic Colitis |
title_full_unstemmed |
Dietary Chicory Inulin-Rich Meal Exerts Greater Healing Effects than Fructooligosaccharide Preparation in Rats with Trinitrobenzenesulfonic Acid-Induced Necrotic Colitis |
title_sort |
dietary chicory inulin-rich meal exerts greater healing effects than fructooligosaccharide preparation in rats with trinitrobenzenesulfonic acid-induced necrotic colitis |
publisher |
Institute of Animal Reproduction and Food Research |
series |
Polish Journal of Food and Nutrition Sciences |
issn |
2083-6007 |
publishDate |
2019-03-01 |
description |
The aim of the study was to compare the effects of chicory root inulin-rich meal (containing polyphenolic fraction as well) and pure fructooligosaccharides (FOS) on necrotic colitis induced with trinitrobenzenesulfonic acid (TNBS) in Wistar rats. Both chicory preparations significantly reduced the pH of colonic digesta and favourably lowered the caecal activity of bacterial β-glucuronidase as well as the caecal concentration of putrefactive short-chain fatty acids in comparison to the control TNBS rats. Both chicory preparations enhanced the production of total short-chain fatty acid (SCFA pool) and concentration of anti-inflammatory propionic acid in the caecal digesta. Nevertheless, only dietary chicory meal favourably increased the total SCFA concentration and thus decreased the pH of caecal digesta. Increased caecal SCFA production may explain observed greater reduction in mucosal necrosis and increase in glandular mucosal regeneration in rats fed a diet with chicory root meal. Both chicory preparations beneficially regulated physiological parameters in the lower part of the rat intestinal tract after TNBS-induced colitis, however the dietary treatment with chicory meal showed stronger reduction of mucosal disturbances caused by colitis. Those beneficial effects might be related to higher polymerization of inulin vs. FOS and presence of biologically active compounds in the meal, i.e., phenolic compounds, which have strong impact on intestinal microbial activity and thus indirectly alleviated mucosal disturbances caused by colitis. |
topic |
tnbs-induced colitis microbiota activity short-chain fatty acids chicory roots wistar rat |
url |
http://www.journalssystem.com/pjfns/Dietary-chicory-inulin-rich-meal-exerts-greater-healing-effects-than-fructooligosaccharide,104611,0,2.html |
work_keys_str_mv |
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