Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing

Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing

The NUP214-ABL1 fusion gene is a constitutively active tyrosine kinase that can be detected in 6% of T-cell acute lymphoblastic leukemia (T-ALL) patients, and it can also be found in B-cell acute lymphoblastic leukaemia (B-ALL). However the NUP214-ABL1 fusion in acute myeloid leukemia (AML) has not...

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Main Authors: Huan-Ping Wang, Jun-Jun He, Qiao-Yun Zhu, Lin Wang, Jian-Hu Li, Jian-Song Huang, Wan-Zhuo Xie, Hong-Hu Zhu, Jie Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
ABL1
NUP214-ABL1
acute myeloid leukemia
tyrosine kinase
next-generation sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.706798/full
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spelling doaj-1ad2c985090e430da94d0023801ceca62021-07-08T06:38:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-07-011110.3389/fonc.2021.706798706798Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation SequencingHuan-Ping Wang0Huan-Ping Wang1Jun-Jun He2Qiao-Yun Zhu3Lin Wang4Jian-Hu Li5Jian-Song Huang6Jian-Song Huang7Wan-Zhuo Xie8Hong-Hu Zhu9Hong-Hu Zhu10Jie Jin11Jie Jin12Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaZhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaCentral Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaZhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, ChinaDepartment of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaZhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, ChinaDepartment of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaZhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, ChinaThe NUP214-ABL1 fusion gene is a constitutively active tyrosine kinase that can be detected in 6% of T-cell acute lymphoblastic leukemia (T-ALL) patients, and it can also be found in B-cell acute lymphoblastic leukaemia (B-ALL). However the NUP214-ABL1 fusion in acute myeloid leukemia (AML) has not yet been reported. Up to now, the sensitivity of NUP214-ABL1-positive patients to tyrosine kinase inhibitor (TKI) is still controversial. Here we report the first case of an AML patient carrying NUP214-ABL1 fusion gene. The conventional AML chemotherapy regimen for the patient was successful. Identification of additional AML patients with NUP214-ABL1 fusion gene will provide treatment experience and prognostic evaluation.https://www.frontiersin.org/articles/10.3389/fonc.2021.706798/fullABL1NUP214-ABL1acute myeloid leukemiatyrosine kinasenext-generation sequencing
collection DOAJ
language English
format Article
sources DOAJ
author Huan-Ping Wang
Huan-Ping Wang
Jun-Jun He
Qiao-Yun Zhu
Lin Wang
Jian-Hu Li
Jian-Song Huang
Jian-Song Huang
Wan-Zhuo Xie
Hong-Hu Zhu
Hong-Hu Zhu
Jie Jin
Jie Jin
spellingShingle Huan-Ping Wang
Huan-Ping Wang
Jun-Jun He
Qiao-Yun Zhu
Lin Wang
Jian-Hu Li
Jian-Song Huang
Jian-Song Huang
Wan-Zhuo Xie
Hong-Hu Zhu
Hong-Hu Zhu
Jie Jin
Jie Jin
Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
Frontiers in Oncology
ABL1
NUP214-ABL1
acute myeloid leukemia
tyrosine kinase
next-generation sequencing
author_facet Huan-Ping Wang
Huan-Ping Wang
Jun-Jun He
Qiao-Yun Zhu
Lin Wang
Jian-Hu Li
Jian-Song Huang
Jian-Song Huang
Wan-Zhuo Xie
Hong-Hu Zhu
Hong-Hu Zhu
Jie Jin
Jie Jin
author_sort Huan-Ping Wang
title Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
title_short Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
title_full Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
title_fullStr Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
title_full_unstemmed Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
title_sort case report: the first report of nup214-abl1 fusion gene in acute myeloid leukemia patient detected by next-generation sequencing
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2021-07-01
description The NUP214-ABL1 fusion gene is a constitutively active tyrosine kinase that can be detected in 6% of T-cell acute lymphoblastic leukemia (T-ALL) patients, and it can also be found in B-cell acute lymphoblastic leukaemia (B-ALL). However the NUP214-ABL1 fusion in acute myeloid leukemia (AML) has not yet been reported. Up to now, the sensitivity of NUP214-ABL1-positive patients to tyrosine kinase inhibitor (TKI) is still controversial. Here we report the first case of an AML patient carrying NUP214-ABL1 fusion gene. The conventional AML chemotherapy regimen for the patient was successful. Identification of additional AML patients with NUP214-ABL1 fusion gene will provide treatment experience and prognostic evaluation.
topic ABL1
NUP214-ABL1
acute myeloid leukemia
tyrosine kinase
next-generation sequencing
url https://www.frontiersin.org/articles/10.3389/fonc.2021.706798/full
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