New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp.

New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp.

Two new steroids, dendronesterones D (<b>1</b>) and E (<b>2</b>), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (<b>3</b>), 5&#945;,8&#945;-epidioxy-24(<i>S</i>)- methylcholesta-6,22-di...

Full description

Bibliographic Details
Main Authors: Thanh-Hao Huynh, Pei-Chin Chen, San-Nan Yang, Feng-Yu Lin, Tung-Pin Su, Lo-Yun Chen, Bo-Rong Peng, Chiung-Chin Hu, You-Ying Chen, Zhi-Hong Wen, Tung-Ying Wu, Ping-Jyun Sung
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Marine Drugs
Subjects:
<i>Dendronephthya</i>
dendronesterone
steroid
anti-inflammatory
iNOS
Online Access:https://www.mdpi.com/1660-3397/17/9/530
Description
Summary:Two new steroids, dendronesterones D (<b>1</b>) and E (<b>2</b>), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (<b>3</b>), 5&#945;,8&#945;-epidioxy-24(<i>S</i>)- methylcholesta-6,22-dien-3&#946;-ol (<b>4</b>), and 5&#945;,8&#945;-epidioxy-24(<i>S</i>)-methylcholesta-6,9(11),22-trien-3&#946;-ol (<b>5</b>), were isolated from an octocoral <i>Dendronephthya</i> sp. The structures of steroids <b>1</b> and <b>2</b> were elucidated by using spectroscopic methods and steroid <b>1</b> was found to exhibit significant in vitro anti-inflammatory activity in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.
ISSN:1660-3397

Similar Items