New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp.

Two new steroids, dendronesterones D (1) and E (2), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (3), 5α,8α-epidioxy-24(S)- methylcholesta-6,22-di...

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Main Authors:	Thanh-Hao Huynh, Pei-Chin Chen, San-Nan Yang, Feng-Yu Lin, Tung-Pin Su, Lo-Yun Chen, Bo-Rong Peng, Chiung-Chin Hu, You-Ying Chen, Zhi-Hong Wen, Tung-Ying Wu, Ping-Jyun Sung
Format:	Article
Language:	English
Published:	MDPI AG 2019-09-01
Series:	Marine Drugs
Subjects:	<i>Dendronephthya</i> dendronesterone steroid anti-inflammatory iNOS
Online Access:	https://www.mdpi.com/1660-3397/17/9/530

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spelling	doaj-1ae3b2497ef442fbb0fade121675fcd22020-11-25T02:01:24ZengMDPI AGMarine Drugs1660-33972019-09-0117953010.3390/md17090530md17090530New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp.Thanh-Hao Huynh0Pei-Chin Chen1San-Nan Yang2Feng-Yu Lin3Tung-Pin Su4Lo-Yun Chen5Bo-Rong Peng6Chiung-Chin Hu7You-Ying Chen8Zhi-Hong Wen9Tung-Ying Wu10Ping-Jyun Sung11Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, TaiwanDoctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Pediatrics, E-DA Hospital, School of Medicine, College of Medicine, I-SHOU University, Kaohsiung 804, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanGraduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanChinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, TaiwanGraduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, TaiwanTwo new steroids, dendronesterones D (<b>1</b>) and E (<b>2</b>), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (<b>3</b>), 5α,8α-epidioxy-24(<i>S</i>)- methylcholesta-6,22-dien-3β-ol (<b>4</b>), and 5α,8α-epidioxy-24(<i>S</i>)-methylcholesta-6,9(11),22-trien-3β-ol (<b>5</b>), were isolated from an octocoral <i>Dendronephthya</i> sp. The structures of steroids <b>1</b> and <b>2</b> were elucidated by using spectroscopic methods and steroid <b>1</b> was found to exhibit significant in vitro anti-inflammatory activity in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.https://www.mdpi.com/1660-3397/17/9/530<i>Dendronephthya</i>dendronesteronesteroidanti-inflammatoryiNOS
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Thanh-Hao Huynh Pei-Chin Chen San-Nan Yang Feng-Yu Lin Tung-Pin Su Lo-Yun Chen Bo-Rong Peng Chiung-Chin Hu You-Ying Chen Zhi-Hong Wen Tung-Ying Wu Ping-Jyun Sung
spellingShingle	Thanh-Hao Huynh Pei-Chin Chen San-Nan Yang Feng-Yu Lin Tung-Pin Su Lo-Yun Chen Bo-Rong Peng Chiung-Chin Hu You-Ying Chen Zhi-Hong Wen Tung-Ying Wu Ping-Jyun Sung New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp. Marine Drugs <i>Dendronephthya</i> dendronesterone steroid anti-inflammatory iNOS
author_facet	Thanh-Hao Huynh Pei-Chin Chen San-Nan Yang Feng-Yu Lin Tung-Pin Su Lo-Yun Chen Bo-Rong Peng Chiung-Chin Hu You-Ying Chen Zhi-Hong Wen Tung-Ying Wu Ping-Jyun Sung
author_sort	Thanh-Hao Huynh
title	New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp.
title_short	New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp.
title_full	New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp.
title_fullStr	New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp.
title_full_unstemmed	New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp.
title_sort	new 1,4-dienonesteroids from the octocoral <i>dendronephthya</i> sp.
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2019-09-01
description	Two new steroids, dendronesterones D (<b>1</b>) and E (<b>2</b>), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (<b>3</b>), 5α,8α-epidioxy-24(<i>S</i>)- methylcholesta-6,22-dien-3β-ol (<b>4</b>), and 5α,8α-epidioxy-24(<i>S</i>)-methylcholesta-6,9(11),22-trien-3β-ol (<b>5</b>), were isolated from an octocoral <i>Dendronephthya</i> sp. The structures of steroids <b>1</b> and <b>2</b> were elucidated by using spectroscopic methods and steroid <b>1</b> was found to exhibit significant in vitro anti-inflammatory activity in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.
topic	<i>Dendronephthya</i> dendronesterone steroid anti-inflammatory iNOS
url	https://www.mdpi.com/1660-3397/17/9/530
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New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp.

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