New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp.
Two new steroids, dendronesterones D (<b>1</b>) and E (<b>2</b>), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (<b>3</b>), 5α,8α-epidioxy-24(<i>S</i>)- methylcholesta-6,22-di...
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doaj-1ae3b2497ef442fbb0fade121675fcd22020-11-25T02:01:24ZengMDPI AGMarine Drugs1660-33972019-09-0117953010.3390/md17090530md17090530New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp.Thanh-Hao Huynh0Pei-Chin Chen1San-Nan Yang2Feng-Yu Lin3Tung-Pin Su4Lo-Yun Chen5Bo-Rong Peng6Chiung-Chin Hu7You-Ying Chen8Zhi-Hong Wen9Tung-Ying Wu10Ping-Jyun Sung11Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, TaiwanDoctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Pediatrics, E-DA Hospital, School of Medicine, College of Medicine, I-SHOU University, Kaohsiung 804, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanGraduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanChinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, TaiwanGraduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, TaiwanTwo new steroids, dendronesterones D (<b>1</b>) and E (<b>2</b>), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (<b>3</b>), 5α,8α-epidioxy-24(<i>S</i>)- methylcholesta-6,22-dien-3β-ol (<b>4</b>), and 5α,8α-epidioxy-24(<i>S</i>)-methylcholesta-6,9(11),22-trien-3β-ol (<b>5</b>), were isolated from an octocoral <i>Dendronephthya</i> sp. The structures of steroids <b>1</b> and <b>2</b> were elucidated by using spectroscopic methods and steroid <b>1</b> was found to exhibit significant in vitro anti-inflammatory activity in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.https://www.mdpi.com/1660-3397/17/9/530<i>Dendronephthya</i>dendronesteronesteroidanti-inflammatoryiNOS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thanh-Hao Huynh Pei-Chin Chen San-Nan Yang Feng-Yu Lin Tung-Pin Su Lo-Yun Chen Bo-Rong Peng Chiung-Chin Hu You-Ying Chen Zhi-Hong Wen Tung-Ying Wu Ping-Jyun Sung |
spellingShingle |
Thanh-Hao Huynh Pei-Chin Chen San-Nan Yang Feng-Yu Lin Tung-Pin Su Lo-Yun Chen Bo-Rong Peng Chiung-Chin Hu You-Ying Chen Zhi-Hong Wen Tung-Ying Wu Ping-Jyun Sung New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp. Marine Drugs <i>Dendronephthya</i> dendronesterone steroid anti-inflammatory iNOS |
author_facet |
Thanh-Hao Huynh Pei-Chin Chen San-Nan Yang Feng-Yu Lin Tung-Pin Su Lo-Yun Chen Bo-Rong Peng Chiung-Chin Hu You-Ying Chen Zhi-Hong Wen Tung-Ying Wu Ping-Jyun Sung |
author_sort |
Thanh-Hao Huynh |
title |
New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp. |
title_short |
New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp. |
title_full |
New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp. |
title_fullStr |
New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp. |
title_full_unstemmed |
New 1,4-Dienonesteroids from the Octocoral <i>Dendronephthya</i> sp. |
title_sort |
new 1,4-dienonesteroids from the octocoral <i>dendronephthya</i> sp. |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2019-09-01 |
description |
Two new steroids, dendronesterones D (<b>1</b>) and E (<b>2</b>), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (<b>3</b>), 5α,8α-epidioxy-24(<i>S</i>)- methylcholesta-6,22-dien-3β-ol (<b>4</b>), and 5α,8α-epidioxy-24(<i>S</i>)-methylcholesta-6,9(11),22-trien-3β-ol (<b>5</b>), were isolated from an octocoral <i>Dendronephthya</i> sp. The structures of steroids <b>1</b> and <b>2</b> were elucidated by using spectroscopic methods and steroid <b>1</b> was found to exhibit significant in vitro anti-inflammatory activity in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. |
topic |
<i>Dendronephthya</i> dendronesterone steroid anti-inflammatory iNOS |
url |
https://www.mdpi.com/1660-3397/17/9/530 |
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