Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis
Objectives: The epidemiology of disease caused by group B Streptococcus (GBS; Streptococcus agalactiae) outside pregnancy and the neonatal period is poorly characterized. The aim of this study was to quantify the role of GBS as a cause of surgical site and non-invasive infections at all ages. Method...
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doaj-1ae902e8ab1e4b68aa10de2b1414c9672020-11-24T20:42:24ZengElsevierInternational Journal of Infectious Diseases1201-97122019-06-0183116129Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysisSimon M. Collin0Nandini Shetty1Rebecca Guy2Victoria N. Nyaga3Ann Bull4Michael J. Richards5Tjallie I.I. van der Kooi6Mayke B.G. Koek7Mary De Almeida8Sally A. Roberts9Theresa Lamagni10Healthcare-Associated Infection and Antimicrobial Resistance (HCAI & AMR) Division, National Infection Service, Public Health England, London, UK; Corresponding author at: Healthcare-Associated Infection and Antimicrobial Resistance (HCAI & AMR) Division, National Infection Service, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.Healthcare-Associated Infection and Antimicrobial Resistance (HCAI & AMR) Division, National Infection Service, Public Health England, London, UKHealthcare-Associated Infection and Antimicrobial Resistance (HCAI & AMR) Division, National Infection Service, Public Health England, London, UKSCIENSANO, Unit of Cancer Epidemiology, Belgian Cancer Centre, Brussels, BelgiumVICNISS Coordinating Centre, The Peter Doherty Institute for Infection and Immunity, Melbourne, AustraliaVICNISS Coordinating Centre, The Peter Doherty Institute for Infection and Immunity, Melbourne, AustraliaDepartment of Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The NetherlandsDepartment of Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The NetherlandsMicrobiology Department, LabPlus, Auckland District Health Board, Auckland, New ZealandMicrobiology Department, LabPlus, Auckland District Health Board, Auckland, New ZealandHealthcare-Associated Infection and Antimicrobial Resistance (HCAI & AMR) Division, National Infection Service, Public Health England, London, UKObjectives: The epidemiology of disease caused by group B Streptococcus (GBS; Streptococcus agalactiae) outside pregnancy and the neonatal period is poorly characterized. The aim of this study was to quantify the role of GBS as a cause of surgical site and non-invasive infections at all ages. Methods: A systematic review (PROSPERO CRD42017068914) and meta-analysis of GBS as a proportion (%) of bacterial isolates from surgical site infection (SSI), skin/soft tissue infection (SSTI), urinary tract infection (UTI), and respiratory tract infection (RTI) was conducted. Results: Seventy-four studies and data sources were included, covering 67 countries. In orthopaedic surgery, GBS accounted for 0.37% (95% confidence interval (CI) 0.08–1.68%), 0.87% (95% CI 0.33–2.28%), and 1.46% (95% CI 0.49–4.29%) of superficial, deep, and organ/space SSI, respectively. GBS played a more significant role as a cause of post-caesarean section SSI, detected in 2.92% (95% CI 1.51–5.55%), 1.93% (95% CI 0.97–3.81%), and 9.69% (95% CI 6.72–13.8%) of superficial, deep, and organ/space SSI. Of the SSTI isolates, 1.89% (95% CI 1.16–3.05%) were GBS. The prevalence of GBS in community and hospital UTI isolates was 1.61% (1.13–2.30%) and 0.73% (0.43–1.23%), respectively. GBS was uncommonly associated with RTI, accounting for 0.35% (95% CI 0.19–0.63%) of community and 0.27% (95% CI 0.15–0.48%) of hospital RTI isolates. Conclusions: GBS is implicated in a small proportion of surgical site and non-invasive infections, but a substantial proportion of invasive SSI post-caesarean section. Keywords: Streptococcus agalactiae, Surgical site infection, Urinary tract infection, Respiratory tract infection, Skin and soft tissue infectionhttp://www.sciencedirect.com/science/article/pii/S1201971219301870 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Simon M. Collin Nandini Shetty Rebecca Guy Victoria N. Nyaga Ann Bull Michael J. Richards Tjallie I.I. van der Kooi Mayke B.G. Koek Mary De Almeida Sally A. Roberts Theresa Lamagni |
spellingShingle |
Simon M. Collin Nandini Shetty Rebecca Guy Victoria N. Nyaga Ann Bull Michael J. Richards Tjallie I.I. van der Kooi Mayke B.G. Koek Mary De Almeida Sally A. Roberts Theresa Lamagni Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis International Journal of Infectious Diseases |
author_facet |
Simon M. Collin Nandini Shetty Rebecca Guy Victoria N. Nyaga Ann Bull Michael J. Richards Tjallie I.I. van der Kooi Mayke B.G. Koek Mary De Almeida Sally A. Roberts Theresa Lamagni |
author_sort |
Simon M. Collin |
title |
Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis |
title_short |
Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis |
title_full |
Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis |
title_fullStr |
Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis |
title_full_unstemmed |
Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis |
title_sort |
group b streptococcus in surgical site and non-invasive bacterial infections worldwide: a systematic review and meta-analysis |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2019-06-01 |
description |
Objectives: The epidemiology of disease caused by group B Streptococcus (GBS; Streptococcus agalactiae) outside pregnancy and the neonatal period is poorly characterized. The aim of this study was to quantify the role of GBS as a cause of surgical site and non-invasive infections at all ages. Methods: A systematic review (PROSPERO CRD42017068914) and meta-analysis of GBS as a proportion (%) of bacterial isolates from surgical site infection (SSI), skin/soft tissue infection (SSTI), urinary tract infection (UTI), and respiratory tract infection (RTI) was conducted. Results: Seventy-four studies and data sources were included, covering 67 countries. In orthopaedic surgery, GBS accounted for 0.37% (95% confidence interval (CI) 0.08–1.68%), 0.87% (95% CI 0.33–2.28%), and 1.46% (95% CI 0.49–4.29%) of superficial, deep, and organ/space SSI, respectively. GBS played a more significant role as a cause of post-caesarean section SSI, detected in 2.92% (95% CI 1.51–5.55%), 1.93% (95% CI 0.97–3.81%), and 9.69% (95% CI 6.72–13.8%) of superficial, deep, and organ/space SSI. Of the SSTI isolates, 1.89% (95% CI 1.16–3.05%) were GBS. The prevalence of GBS in community and hospital UTI isolates was 1.61% (1.13–2.30%) and 0.73% (0.43–1.23%), respectively. GBS was uncommonly associated with RTI, accounting for 0.35% (95% CI 0.19–0.63%) of community and 0.27% (95% CI 0.15–0.48%) of hospital RTI isolates. Conclusions: GBS is implicated in a small proportion of surgical site and non-invasive infections, but a substantial proportion of invasive SSI post-caesarean section. Keywords: Streptococcus agalactiae, Surgical site infection, Urinary tract infection, Respiratory tract infection, Skin and soft tissue infection |
url |
http://www.sciencedirect.com/science/article/pii/S1201971219301870 |
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