“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability

A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolat...

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Bibliographic Details
Main Authors: Ana Gomes, Lucinda J. Bessa, Patrícia Correia, Iva Fernandes, Ricardo Ferraz, Paula Gameiro, Cátia Teixeira, Paula Gomes
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
antibacterial
antibiofilm
ionic liquid
multidrug resistance
peptide
skin infections
Online Access:https://www.mdpi.com/1422-0067/21/17/6174
Description
Summary:A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of <i>Klebsiella pneumoniae</i>, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.
ISSN:1661-6596
1422-0067

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