Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta
Introduction: Angiogenesis is a dynamic procedure that plays a key role in physiological and pathological conditions such as tumor growth. Today, the green synthesized nanoparticles are applied for cancer treatment due to their anti-angiogenic properties. In the green method, the plant extract is us...
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Ilam University of Medical Sciences
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doaj-1af235b3894348efaba886635875612a2020-11-24T22:25:29Zfas Ilam University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām1563-47282588-31352018-06-012624555Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistortaElham Safavi0Masoud Homayouni Tabrizi1Ehsan Karimi2 Dept of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran Dept of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran Dept of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran Introduction: Angiogenesis is a dynamic procedure that plays a key role in physiological and pathological conditions such as tumor growth. Today, the green synthesized nanoparticles are applied for cancer treatment due to their anti-angiogenic properties. In the green method, the plant extract is used for metal ions exchange into a nanoparticle as an economic and environmental-friendly procedure. In the present study, the anti-angiogenic effects of green ZnO nanoparticles synthesized by Persicaria bistorta root extract were evaluated. Materials & Methods : As to investigate the anti-angiogenic effects of green synthesized ZnO nanoparticles, 30 Ross eggs were randomly divided into 6 groups including the control ,laboratory control, and 4 experimental groups treated by 250, 500, 1000, and 2000 μg/ml ZnO nanoparticles. On the day 12 after incubation, the effects of ZnO were assessed. The obtained data was analyzed using the SPSS software and ANOVA statistical test. The P<0.05 was regarded as a significance. Findings: The obtained data showed that the 1000 and 2000 μg/ml of green synthesized ZnO nanoparticles significantly decreased the number and length of chorioallantoic membrane vascular splits (P<0.001), weight and size and the head to tail length of the chicken’s embryos in comparison to the normal controls (P<0.05). Discussion & Conclusion: Our results demonstrated that the green ZnO nanoparticles synthesized by aqueous Persicaria bistorta root extract restricted the angiogenesis.http://sjimu.medilam.ac.ir/browse.php?a_code=A-10-2110-5&slc_lang=en&sid=1angiogenesis ZnO Chorioallantoic membrane |
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language |
fas |
format |
Article |
sources |
DOAJ |
author |
Elham Safavi Masoud Homayouni Tabrizi Ehsan Karimi |
spellingShingle |
Elham Safavi Masoud Homayouni Tabrizi Ehsan Karimi Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām angiogenesis ZnO Chorioallantoic membrane |
author_facet |
Elham Safavi Masoud Homayouni Tabrizi Ehsan Karimi |
author_sort |
Elham Safavi |
title |
Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta |
title_short |
Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta |
title_full |
Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta |
title_fullStr |
Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta |
title_full_unstemmed |
Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta |
title_sort |
investigation of antiangiogenic properties of green zno nanoparticles synthesized by root extract of persicaria bistorta |
publisher |
Ilam University of Medical Sciences |
series |
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
issn |
1563-4728 2588-3135 |
publishDate |
2018-06-01 |
description |
Introduction: Angiogenesis is a dynamic procedure that plays a key role in physiological and pathological conditions such as tumor growth. Today, the green synthesized nanoparticles are applied for cancer treatment due to their anti-angiogenic properties. In the green method, the plant extract is used for metal ions exchange into a nanoparticle as an economic and environmental-friendly procedure. In the present study, the anti-angiogenic effects of green ZnO nanoparticles synthesized by Persicaria bistorta root extract were evaluated.
Materials & Methods : As to investigate the anti-angiogenic effects of green synthesized ZnO nanoparticles, 30 Ross eggs were randomly divided into 6 groups including the control ,laboratory control, and 4 experimental groups treated by 250, 500, 1000, and 2000 μg/ml ZnO nanoparticles. On the day 12 after incubation, the effects of ZnO were assessed. The obtained data was analyzed using the SPSS software and ANOVA statistical test. The P<0.05 was regarded as a significance.
Findings: The obtained data showed that the 1000 and 2000 μg/ml of green synthesized ZnO nanoparticles significantly decreased the number and length of chorioallantoic membrane vascular splits (P<0.001), weight and size and the head to tail length of the chicken’s embryos in comparison to the normal controls (P<0.05).
Discussion & Conclusion: Our results demonstrated that the green ZnO nanoparticles synthesized by aqueous Persicaria bistorta root extract restricted the angiogenesis. |
topic |
angiogenesis ZnO Chorioallantoic membrane |
url |
http://sjimu.medilam.ac.ir/browse.php?a_code=A-10-2110-5&slc_lang=en&sid=1 |
work_keys_str_mv |
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