Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses
Colic horses show systemic inflammatory response syndrome (SIRS) clinical signs. Procalcitonin (PCT) showed increased circulating levels in sick horses. This study compares plasma PCT concentrations in healthy vs. SIRS negative/positive colic horses over time, and evaluates PCT and SIRS score potent...
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doaj-1af7fa84d27d440b8bc891e12d04546d2021-07-23T13:27:29ZengMDPI AGAnimals2076-26152021-07-01112015201510.3390/ani11072015Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic HorsesIrene Nocera0Francesca Bonelli1Valentina Vitale2Valentina Meucci3Giuseppe Conte4Eduard Jose-Cunilleras5Luis Alfonso Gracia-Calvo6Micaela Sgorbini7Department of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, via Livornese snc, San Piero a Grado, 56124 Pisa, ItalyDepartment of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, via Livornese snc, San Piero a Grado, 56124 Pisa, ItalyDepartment of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, via Livornese snc, San Piero a Grado, 56124 Pisa, ItalyDepartment of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, via Livornese snc, San Piero a Grado, 56124 Pisa, ItalyDepartment of Agriculture, Food, Environment, University of Pisa, via del Borghetto, 80, 56124 Pisa, ItalyEquine Internal Medicine Service, Veterinary Teaching Hospital, Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Autonomous University of Barcelona, 08193 Barcelona, SpainVeterinary Teaching Hospital, University of Helsinki, Koetilankuja 1, 00790 Helsinki, FinlandDepartment of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, via Livornese snc, San Piero a Grado, 56124 Pisa, ItalyColic horses show systemic inflammatory response syndrome (SIRS) clinical signs. Procalcitonin (PCT) showed increased circulating levels in sick horses. This study compares plasma PCT concentrations in healthy vs. SIRS negative/positive colic horses over time, and evaluates PCT and SIRS score potential correlation, to verify the usefulness of PCT for the evaluation of SIRS severity. Ninety-one horses were included; 43/91 were healthy, on basis of physical examination, blood work and SIRS score (score = 0), while 48/91 were sick colic horses, classified as SIRS-negative (score < 2) and positive (score ≥ 2). Moreover, a 0–6 point-scale SIRS score was calculated (assessing mucous membrane color and blood lactate concentration). PCT was evaluated at admission, and at 24, 48, 72 and 96 h, using a commercial kit for equine species. We verified by the ANOVA test PCT differences between healthy vs. colic horses, healthy vs. SIRS-negative or SIRS-positive colic horses, at all sampling times, and the correlation between the SIRS score at admission with the SIRS score. Statistically significant differences were detected between healthy vs. all colic horses and between healthy vs. SIRS-positive or negative horses at all sampling times. No correlation was observed between the SIRS score at admission and PCT values. PCT was statistically higher in colic horses compared to the healthy ones, suggesting a role as a biomarker for colic.https://www.mdpi.com/2076-2615/11/7/2015horsecolicprocalcitoninsystemic inflammatory response syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Irene Nocera Francesca Bonelli Valentina Vitale Valentina Meucci Giuseppe Conte Eduard Jose-Cunilleras Luis Alfonso Gracia-Calvo Micaela Sgorbini |
spellingShingle |
Irene Nocera Francesca Bonelli Valentina Vitale Valentina Meucci Giuseppe Conte Eduard Jose-Cunilleras Luis Alfonso Gracia-Calvo Micaela Sgorbini Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses Animals horse colic procalcitonin systemic inflammatory response syndrome |
author_facet |
Irene Nocera Francesca Bonelli Valentina Vitale Valentina Meucci Giuseppe Conte Eduard Jose-Cunilleras Luis Alfonso Gracia-Calvo Micaela Sgorbini |
author_sort |
Irene Nocera |
title |
Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses |
title_short |
Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses |
title_full |
Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses |
title_fullStr |
Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses |
title_full_unstemmed |
Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses |
title_sort |
evaluation of plasmatic procalcitonin in healthy, and in systemic inflammatory response syndrome (sirs) negative or positive colic horses |
publisher |
MDPI AG |
series |
Animals |
issn |
2076-2615 |
publishDate |
2021-07-01 |
description |
Colic horses show systemic inflammatory response syndrome (SIRS) clinical signs. Procalcitonin (PCT) showed increased circulating levels in sick horses. This study compares plasma PCT concentrations in healthy vs. SIRS negative/positive colic horses over time, and evaluates PCT and SIRS score potential correlation, to verify the usefulness of PCT for the evaluation of SIRS severity. Ninety-one horses were included; 43/91 were healthy, on basis of physical examination, blood work and SIRS score (score = 0), while 48/91 were sick colic horses, classified as SIRS-negative (score < 2) and positive (score ≥ 2). Moreover, a 0–6 point-scale SIRS score was calculated (assessing mucous membrane color and blood lactate concentration). PCT was evaluated at admission, and at 24, 48, 72 and 96 h, using a commercial kit for equine species. We verified by the ANOVA test PCT differences between healthy vs. colic horses, healthy vs. SIRS-negative or SIRS-positive colic horses, at all sampling times, and the correlation between the SIRS score at admission with the SIRS score. Statistically significant differences were detected between healthy vs. all colic horses and between healthy vs. SIRS-positive or negative horses at all sampling times. No correlation was observed between the SIRS score at admission and PCT values. PCT was statistically higher in colic horses compared to the healthy ones, suggesting a role as a biomarker for colic. |
topic |
horse colic procalcitonin systemic inflammatory response syndrome |
url |
https://www.mdpi.com/2076-2615/11/7/2015 |
work_keys_str_mv |
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